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肠道细菌产物胞壁酰二肽的研究进展 被引量:1

Advances in the study of muramidyl dipeptides from intestinal bacteria
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摘要 肠道被称为多器官功能障碍综合征的发动机,肠源性脓毒症和肠道细菌移位在危重症救治中日益受到关注。肠道细菌移位的重要途径之一是细菌产物移位。而作为革兰氏阳性菌和阴性菌的细胞壁最小肽聚糖免疫活性物质,细菌产物胞壁酰二肽(muramyl dipeptide,MDP)肠道移位对机体的免疫与代谢具有重大的影响。本文重点关注MDP的肠道移位机制及其调控方法(包括MDP转运途径、作用靶点、信号通路和炎性损伤路径),聚焦MDP对免疫和代谢的影响。
作者 赵璐佳 石斌 庞秀峰 Zhao Lujia;Shi Bin;Pang Xiufeng
出处 《老年医学与保健》 CAS 2023年第1期148-152,共5页 Geriatrics & Health Care
基金 中华国际医学交流基金会黎介寿肠道屏障研究基金(Z-2017-24-2026) 上海市卫生健康委员会科研基金(202240064)。
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