摘要
帕金森病(Parkinson’s disease,PD)是一种中老年常见的神经系统退行性疾病。PD的主要病理特点是黑质致密部的多巴胺能神经元丢失,进而使纹状体内的多巴胺水平降低。目前PD的发病原因尚不完全清楚,该文从遗传因素、环境因素、线粒体功能障碍、氧化应激、氮化应激、免疫炎性反应异常、细胞凋亡学说和神经递质失衡等方面系统综述了近年来PD的病理机制,以期为PD的深入研究提供参考资料。
Parkinson's disease is a common degenerative disease of the nervous system in elderly people. The main pathological features of Parkinson's substantia nigra is the disappearance of dopamine neurons, which reduces the dopamine level in the striatum. This paper summarized the pathogenesis of Parkinson's disease in recent years in several aspects, including genetic factors, environmental factors, mitochondrial dysfunction, oxidative stress, nitrogen stress, abnormal immune inflammatory response, apoptosis doctrine and neurotransmitter imbalances. This review provides a theoretical basis for further study of Parkinson's disease.
出处
《神经药理学报》
2013年第2期35-42,共8页
Acta Neuropharmacologica
基金
辽宁省高等学校创新团队课题(No.LT2013020)
关键词
帕金森病
分子水平
病理机制
Parkinson's disease
molecular level
pathological mechanisms
