摘要
目的探究抗菌药物的用药时机对剖宫产妇术后感染的预防效果及炎性因子水平的影响。方法选取2015年1月-2017年10月医院行剖宫产术产妇82例为研究对象。根据随机数表法将产妇分为两组,研究组(n=42)术前30min行2g头孢曲松钠静脉滴注,术后连续3d给药;对照组(n=40)仅术后连续3d给予头孢曲松钠,2g/次,1次/d。观察比较两组手术情况、术后感染率、炎性因子水平。结果两组手术时间、手术出血量比较差异无统计学意义;研究组术后体温恢复时间、住院时间为(39.67±4.16)h、(4.92±1.03)d,短于对照组,差异有统计学意义(P<0.05)。术后感染总发生率研究组(4.76%)低于对照组,差异有统计学意义(P<0.05)。术前两组炎性因子IL-6、CRP、PCT水平比较差异无统计学意义;术后1d研究组为(98.23±13.62)pg/ml、(2.81±0.64)mg/L、(2.91±0.85)μg/L低于对照组,差异有统计学意义(P<0.05);术后3d研究组为(79.14±9.86)pg/ml、(1.98±0.43)mg/L、(1.91±0.45)μg/L低于对照组,差异有统计学意义(P<0.05)。结论术前30min预防性运用抗菌药物有利于减轻剖宫产妇炎性因子水平,降低术后感染发生率,缩短住院时间。
OBJECTIVE To explore the effects of medication timing on postoperative infection in cesarean section puerpera and the levels of inflammatory factors.METHODS A total of 82 puerpera who received cesarean section in the hospital from Jan 2015 to Oct 2017 were recruited as the study objects and randomly divided into the study group with 42 cases and the control group with 40 cases,the study group was treated with intravenous drip of 2 g ceftriaxone sodium 30 min before the surgery and treated for 3 consecutive days after the surgery,while the control group was only given ceftriaxone sodium after the surgery,2 g once,once per day.The surgical indexes,incidence of postoperative infection and levels of inflammatory factors were observed and compared between the two groups.RESULTS There were no significant differences in the operation duration and surgical bleeding volume between the two groups.The time of recovery of postoperative body temperature of the study group was(39.67±4.16)hours,sighificantly shorter than that of the control group,the length of hospital stay of the study group was(4.92±1.03)days,sighificantly shorter than that of the control group(P<0.05).The total incidence rate of postoperative infection of the study group was 4.86%,sighificantly lower than that of the control group(P<0.05).There were no significant differences in the levels of inflammatory factors IL-6,CRP and PCT between the two groups before the surgery;the levels of IL-6,CRP and PCT of the study group were respectively(98.23±13.62)pg/ml,(2.81±0.64)mg/L and(2.91±0.85)μg/L after the surgery for 1 day,lower than those of the control group(P<0.05);the levels of IL-6,CRP and PCT of the study group were respectively(79.14±9.86)pg/ml,(1.98±0.43)mg/L and(1.91±0.45)μg/L after the surgery for 3 days,sighificantly lower than those of the control group(P<0.05).CONCLUSIONThe prophylactic use of antibiotics 30 min before the surgery may reduce the levels of inflammatory factors of the cesarean section puerpera and the incidence of postoperativ
作者
黄淑梅
熊亚君
邱玲俐
HUANG Shu-mei;XIONG Ya-jun;QIU Ling-li(Jiujiang Third People's Hospital of Jiangxi Province,Jiujiang,Jiangxi 332000,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2019年第5期759-762,共4页
Chinese Journal of Nosocomiology
基金
江西省自然科学基金资助项目(20391839)
关键词
抗菌药物
用药时机
剖宫产
感染
炎性因子
Antibiotic
Medication timing
Cesarean section
Infection
Inflammatory factor
