摘要
目的:分析剖宫产不同时机应用抗生素对预防术后感染及血清WBC、NEUT、CRP、INF-γ、TNF-α的影响。方法:此次研究对象均为择期行剖宫产手术产妇,共计240例,根据抗菌药物应用时机的差异均分为术前30 min组、术中断脐带组、术毕30 min组,各80例,分别予以术前30 min组、术中断脐带组、术毕30 min组术前30 min、术中断脐带时、术毕30 min后静脉滴注头孢拉定,比较三组术后恢复情况、术后感染发生率、白细胞计数(WBC)、中性粒细胞百分比(NEUT)、血清C-反应蛋白(CRP)、γ干扰素(INF-γ)及肿瘤坏死因子-α(TNF-α)等指标变化。结果:术前30 min组、术中断脐带组两组压疮感染率及泌尿系感染率均明显低于术毕30 min组,差异有统计学意义(P<0.05),且术前30 min组低于术中断脐带组,差异无统计学意义(P>0.05);在WBC及NEUT比较上,术前30 min组、术中断脐带组WBC明显低于术毕30 min组,且术前30 min组WBC明显低于术中断脐带组,差异有统计学意义(P<0.05),三组NEUT比较差异无统计学意义(P>0.05);在CRP、INF-γ、TNF-α的比较上,术前30 min组、术中断脐带组明显优于术毕30 min组,且术前30 min组明显优于术中断脐带组,差异有统计学意义(P<0.05)。结论:予以行剖宫产手术产妇术前30 min静脉滴注抗生素头孢拉定,能够有效促使其术后炎性反应减轻,并减少术后感染,从而促进其术后快速康复,减少住院时间并减轻其医疗负担,具有推广价值。
Objective To analyze and study the effect of antibiotics on the prevention of postoperative infection and serum WBC,neut,CRP,INF-γ,TNF-α.Method The subjects of this study were all 240 parturients who underwent elective cesarean section.According to the differences in the timing of application of antibiotics,they were divided into 30 min before operation group,umbilical cord interruption group,30 min after operation group.80 cases in each group.Cefradine was given intravenously 30 minutes before operation,30 minutes after interruption of umbilical cord and 30 minutes after completion of operation to compare the recovery of the three groups,the changes of infection rate,WBC,neut,CRP,IFN-γand TNF-α.Results The rates of puerperal infection and urinary tract infection in 30 min before operation group and umbilical cord interruption group were significantly lower than those in 30 min after operation group(P<0.05),but there was no significant difference between 30 min before operation group and umbilical cord interruption group(P>0.05);in the comparison of WBC and NEUT,WBC in 30 min before operation group and umbilical cord interruption group was significantly lower than that in 30 min after operation group,and WBC in 30 min before operation group was significantly lower than that in umbilical cord interruption group(P<0.05),but there was no significant difference in NEUT among the three groups(P>0.05);in the comparison of CRP,INF-γ,TNF-α,30 min before operation group and umbilical cord interruption group were better than 30 min after operation group.30 min before operation group was better than umbilical cord interrnption group,the difference was statistically significant(P<0.05).Conclusion Intravenous drip of cefradine 30 minutes before cesarean section can effectively reduce the postoperative inflammatory response and postoperative infection,so as to promote the rapid postoperative recovery,reduce the length of stay and reduce the medical burden.
作者
李英
潘淑媛
冯丽春
LI Ying;PAN Shu-yuan;FENG Li-chun(The People's Hospital of Xinhui District,Jiangmen City,Guangdong Province,Jiangmen 529100,China)
出处
《吉林医学》
CAS
2021年第3期575-577,共3页
Jilin Medical Journal
基金
江门市卫生计生局科学技术研究项目[项目编号:18A060]。
关键词
剖宫产
不同时机
抗生素
术后感染
炎性反应
Cesarean section
Different timing
Antibiotics
Postoperative infection
Inflammatory response
