摘要
目的探讨不同时机应用抗菌药物对于剖宫产妇围术期预防感染的临床效果差异,为临床预防感染的相关研究提供参考借鉴。方法选取2012年12月-2013年12月医院临床收治的剖宫产妇88例为研究对象,根据抗菌药物应用时机分为研究组和对照组,每组各44例,研究组手术前30min给予抗菌药物静脉滴注,对照组手术后给予抗菌药物静脉滴注,观察和比较两组产妇的手术时间、术中出血量、住院时间、切口愈合等级、产褥感染率、血白细胞计数(WBC)异常率、泌尿系感染率、C-反应蛋白(CRP)和降钙素原(PCT)。结果研究组住院时间(7.43±1.36)d明显低于对照组(10.45±2.07)d,差异有统计学意义(P<0.05);研究组产妇的总感染率为4.55%低于对照组34.09%,差异有统计学意义(P<0.05);术后1d研究组产妇CRP和PCT指标分别为(2.75±0.61)mg/L和(2.75±0.97)ng/ml,低于对照组产妇(4.73±0.93)mg/L和(6.78±1.94)ng/ml,差异有统计学意义(P<0.05)。结论在剖宫产手术前30min给予预防性的应用抗菌药物,能够有效降低产妇术后切口感染率,是临床预防产妇感染的有效方式。
OBJECTIVE To investigate the differences of clinical effects of using antibiotics at different time on perioperative infection prevention of cesarean women,so as to provide references for relevant clinical infection prevention.METHODS A total of 88 cases of cesarean section women in the hospital from Dec.2012 to Dec.r 2013 were chosen as research objects.According to the time of using antibiotics,they were divided into study group and control group,with 44 cases in each group.The study group was taken intravenous antibiotics drip 30 min before surgery,and the control group was taken antibiotics intravenously after surgery.The operative time,blood loss,hospital stay,incision healing grade,puerperal infection,white blood cell count（WBC）abnormal rate,urinary system of infection,C-reactive protein（CRP）and procalcitonin（PCT）of the two groups were observed and compared.RESULTS The hospital stay of study group was（7.43±1.36）d,which was significantly lower than that of control group of（10.45±2.07）d（P〈0.05）.The overall infection rate of study group was 4.55%,which was significantly lower than that of control group of 34.09%（P〈0.05）.The CRP and PCT indexes in study group 1day after surgery were（2.75±0.61）mg/L and（2.75±0.97）ng/ml,which were lower than those in control group of（4.73±0.93）mg/L and（6.78±1.94）ng/ml（P〈0.05）.CONCLUSIONThe application of prophylactic antibiotic 30 minutes before cesarean section can effectively reduce the probability of maternal postoperative infections,and it is an effective way to prevent maternal clinical infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第3期660-662,共3页
Chinese Journal of Nosocomiology
基金
河南省卫生厅科研成果(宛科鉴字[2012]第103号99)
关键词
抗菌药物
给药时机
剖宫产
感染
Antibiotics
Timing of administration
Cesarean section
Infection
