摘要
目的探讨调整剖宫产术围术期抗菌药物预防用药时机的临床应用效果。方法选取2018年l月至2019年10月南方医科大学附属南海区人民医院妇产科接收的913例剖宫产产妇作为研究对象,根据其入院先后顺序将其分为断脐后组(n=497)和术前组(n=416),断脐后组于断脐后开始使用第一剂抗菌药物,术前组于皮肤、黏膜切开前0.5~1 h内开始使用第一剂抗菌药物,观察两组剖宫产产妇术后感染率、预防用药疗程(≤24h、24~48 h、>48~72 h、≥72 h)、抗菌药物使用强度、抗菌药物费用、药品总费用及住院时间差异。结果术前组和断脐后组预防性用药后感染率分别为8.41%和13.08%,差异有统计学意义(P<0.05);但术前组预防使用抗菌药物用药疗程、抗菌药物使用强度、抗菌药物及总药品费用更低,差异有统计学意义(P<0.05)。两组的住院时间比较,差异无统计学意义(P>0.05)。结论将剖宫产术围术期抗菌药物预防用药时机调整至于皮肤、黏膜切开前0.5~1 h预防性使用抗菌药物更有利于降低术后感染率,且在使用强度及相关药品费用等方面具有更加明显的优势,临床应用效果良好,值得推广。
Objective To investigate the clinical application efficacy of adjusting the timing of prophylactic medication of antibiotics during perioperative period of cesarean section.Methods A total of 913 pregnant women undergoing cesarean section admitted to the department of pharmacy in the Nanhai District People’s Hospital Affiliated to Southern Medical University from January 2018 to October 2019 were selected as the research objects.According to their admission order,they were divided into the post umbilical cord amputation group(n=497)and the preoperative group(n=416).The first dose of antibiotics in the post umbilical cord amputation group was used after the umbilical cord amputation,while the first dose of antibiotics in the preoperative group was used within 0.5-1 hour before skin and mucosa incision.The differences of postoperative infection rate,prophylactic medication course(≤24 h,24-48 h,>48-72 h,>72 h),antibacterial drug medication intensity,antibacterial drug cost,total drug cost and hospitalization days between the two groups were observed.Results The infection rates of the pre-operation group and post umbilical cord amputation group were 8.41%and 13.08%,respectively,with statistically significant difference(P<0.05).However,the treatment course of prophylactic medication of antibiotics,the intensity of medication of antibiotics,the cost of antibiotics and total drugs in the preoperative group were lower,with statistically significant differences(P<0.05).There was no statistically significant difference in the hospitalization days between the two groups(P>0.05).Conclusion It is more beneficial to reduce the postoperative infection rate by adjusting the prophylactic medication of antibiotics in perioperative period of cesarean section to 0.5-1 hour before skin and mucous membrane incision,and it has more obvious advantages in the medication intensity and related drug costs.It has good clinical application efficacy,which is worthy of promotion.
作者
雷露雯
林敏婷
肖洒
LEI Luwen;LIN Minting;XIAO Sa(Department of Pharmacy,the Nanhai District People's Hospital Affiliated to Southern Medical University,Guangdong,Foshan 528000,China)
出处
《中国医药科学》
2021年第5期93-97,共5页
China Medicine And Pharmacy
基金
广东省佛山市医学类科技攻关项目(2018AB001862)。
关键词
剖宫产术
围术期
预防用药时机
抗菌药物
Cesarean section
Perioperative period
Timing of prophylactic medication
Antibiotics
