摘要
目的对碱性蒙脱石抗酸剂进行性能测定及评价。方法测定抗酸剂的活性成分含量、溶解度及粒度等参数,并进行BET、X-射线衍射法(XRD)和扫描电镜(SEM)表征分析,通过急性毒性实验、体外抗酸实验以及胃黏膜保护实验对抗酸剂进行评价。结果活性成分Ca(OH)2的含量和溶解度分别为37%和84 mg·L-1,活性成分Ca(OH)2负载比较牢固,碱强度大大下降。粒度和比表面积分别为8.3μm和37.5 m2·g-1,有利于吸附胃酸和形成胃黏膜保护。X-射线衍射法表征结果显示,抗酸剂保留了蒙脱石的结构,扫描电镜图谱显示,抗酸剂的表面比较光滑,利于黏膜保护。急性毒性实验、体外抗酸实验和胃黏膜保护实验结果表明,抗酸剂安全无毒,并表现出优良的抗酸和胃黏膜保护性能。结论碱性蒙脱石抗酸剂是一种优良的抗酸剂及胃黏膜保护剂。
OBJECTIVE To investigate and evaluate the antacid property of alkaline montmorillonite. METHODS Parameters of the antacid,such as active component content,solubility,and granularity,were determined. The antacid was characterized by BET,XRD,and SEM,and evaluated by acute toxicity test,acid resistance in vitro experiment,and gastric mucosa protection experiment.RESULTS The content and solubility of the active component Ca( OH)2were 37% and 84 mg·L- 1,respectively,which showed that Ca( OH)2was relatively firmly loaded and the alkalinity was largely decreased. The granularity and specific area were 8. 3 μm and37. 5 m2·g- 1,respectively,which were beneficial to gastric acid adsorption and gastric mucosa protection. Besides,XRD characterization results revealed the antacid retained a structure of montmorillonite. And SEM patterns indicated the surface of the antacid was relatively smooth,which was conducive to gastric mucosa protection. In addition,the results of acute toxicity test,acid resistance in vitro experiment,and gastric mucosa protection experiment demonstrated that the antacid was safe and non-toxic. Meanwhile,it pocessed excellent properties of acid resistance and gastric mucosa protection. CONCLUSION Alkaline montmorillonite antacid is an excellent antacid and gastric mucosa protectant.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2015年第2期157-162,共6页
Chinese Pharmaceutical Journal
基金
国家自然科学基金资助项目(21166004)
关键词
碱性蒙脱石
抗酸剂
胃黏膜保护剂
alkaline montmorillonite
antacid
gastric mucosa protectant
