摘要
介绍了醇脱氢酶的种类,酵母醇脱氢酶和肝醇脱氢酶等两类常用的醇脱氢酶的物理化学性质和活性位点结构.归纳了对肝醇脱氢酶和酵母醇脱氢酶作用机理的研究,重点评述了醇脱氢酶催化反应中的两个关键步骤质子转移和氢化物转移过程机理的研究进展.
The type of alcohol dehydrogenases, the chemical and physical properties and structure of active site of two common types of alcohol dehydrogenase, yeast alcohol dehydrogenase (YADH) and liver alcohol dehydrogenase (LADH) were introduced. Research progress in the kinetic mechanism of YADH and LADH was summarized with special focus on the progress in the proton transfer and hydride transfer, two key steps involved in the dehydrogenase-catalyzed reaction.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2005年第6期629-633,共5页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.20176039)
天津市应用基础研究重点项目(No.033802411)
教育部跨世纪优秀人才培养计划资助项目.
