摘要
目的:探讨长期慢性高原暴露对高原土生牦牛(yak)、高山迁饲黄牛(migrated cattle)和低海拔黄牛(lowland cattle)肾功能的影响,探究牦牛和高山迁饲黄牛适应和习服高原的不同特征及差异。方法:采集青海不同地区的牦牛血样,按海拔高度分为3 000 m,3 500 m,4 000 m和4 300 m四个组(n=84),同时采集高山迁饲黄牛(n=22)及低海拔黄牛(n=39)血液,利用全自动血液生化分析仪测定尿素氮(BUN)、肌酐(Cr)、尿素氮/肌酐(BUN/Cr)、尿酸(UA)、二氧化碳结合率(CO_2cp)、葡萄糖(GLU)水平,分析不同海拔高度的牦牛之间及牦牛、高山迁饲黄牛和低海拔黄牛之间的差异。结果:随着海拔的升高,土生牦牛UA、CO_2cp两项升高较显著,与黄牛相比,BUN、BUN/Cr显著高于高山迁饲黄牛和低海拔黄牛,CO_2cp、GLU显著低于低海拔黄牛。低海拔黄牛和高山迁饲黄牛相比,BUN、BUN/Cr显著低于高山迁饲黄牛,UA、CO_2cp显著高于高山迁饲黄牛。结论:土生牦牛对于高原低氧环境有很强的适应能力;高山迁饲黄牛表现出对低氧的不适应性,处于对低氧的应激状态。
Objective: To investigate the difference of renal function among yak,migrated cattle on Qinghai-tibetan plateau and lowland cattle,and to further explore the characteristics of renal to adapt chronic hypoxia. Methods: The serum samples of yak( n =84) were collected at 3 000 m,3 500 m,4 000 m and 4 300 m respectively,meanwhile the serum samples of migrated cattle on plateau( n = 22) and lowland cattle( n = 39) were also collected. The levels of blood urea nitrogen( BUN),creatinine( Crea),blood urea nitrogen / creatinine( BUN / Cr),uric acid( UA),carbon dioxide binding rate( CO_2cp),glucose( GLU) in serum were measured by using fully automatic blood biochemical analyzer. We analysed the differences among the above renal functions. Results: With the altitude increased,the results showed the levels of UA and CO_2 cp of yak were increased significantly,as compared to cattle,the levels of BUN and BUN / Cr were increased significantly compared with migrated cattle on plateau and lowland cattle,the levels of CO_2 cp and GLU were decreased significantly compared with lowland cattle. As compared to migrated cattle on plateau,the levels of BUN and BUN / Cr of lowland cattle were decreased significantly,the levels of UA and CO_2 cp were increased significantly. Conclusion: The results indicated that the yak were adapted to the plateau hypoxia environment and migrated cattle maybe not adapt to the low oxygen environment,they were under the stress situation.
出处
《中国应用生理学杂志》
CAS
CSCD
2016年第5期440-443,共4页
Chinese Journal of Applied Physiology
基金
科技部973前期资助项目(2012CB722506)
科技部973资助项目(2012CB518202)
关键词
慢性低氧
牦牛
黄牛
肾功能
chronic hypoxia
yak
migrated cattle
renal function
