摘要
生物碱是自然界中广泛存在的一类含氮碱性有机物,具有抗肿瘤、抗癌、降糖等多种生理活性。目前具有减轻或延缓实验动物糖尿病肾病肾脏的病变过程作用的生物碱主要有以下几大类:吡啶衍生物类、吡咯啶衍生物类、莨菪烷衍生物类、异喹啉衍生物类、吡嗪衍生物类、有机胺类和萜类生物碱等。常见的生物碱有小檗碱、川芎嗪、山莨菪碱、甜菜碱、苦参碱、秋水仙碱等。生物碱的肾脏保护作用机制多种多样,包括调节氧化应激、改善胰岛素抵抗、减少炎症因子的浸润、以及下调或增加相关因子的表达等。
Alkaloids are a class of nitrogen-containing alkaloids, which have many physiological activities, such as anti-tumor, and hypoglycemic effects. At present, the main alkaloids that can alleviate or delay the process of diabetic nephropathy in experimental animals include pyridine derivatives, pyrrolidine derivatives, scopolamine derivatives, isoquinoline derivatives, pyridine derivatives, isoquinoline derivatives, pyrazine derivatives, organic amines, and terpene alkaloids. Common alkaloids are berberine, ligustrazine, anisodamine, betaine, matrine, and colchicine, among others. Alkaloids have a variety of mechanisms for renal protection, including regulating oxidative stress, improving insulin resistance, reducing the infiltration of inflammatory factors, and downregulating or increasing the expression of related factors.
作者
赵隆
吉金山
李宝莉
曹净
邓飞龙
席辽
张欣
ZHAO Long;JI Jinshan;LI Baoli;CAO Jing;DENG Feilong;XI Liao;ZHANG Xin(Undergraduate of Medical College of Yan’an University,Yan’an 716000,China.Department of Preventive Medicine,Medical College of Yan’an University,Yan’an 716000.Department of Pharmacology,Medical College of Yan’an University,Yan’an 716000)
出处
《中国比较医学杂志》
CAS
北大核心
2019年第3期117-122,共6页
Chinese Journal of Comparative Medicine
基金
延安大学2017年校级大学生创新创业训练计划项目(D2017181)
关键词
糖尿病肾病
生物碱类化合物
中药
diabetic nephropathy
alkaloid compound
traditional Chinese medicine
