摘要
糖尿病是一种发病率极高的代谢紊乱性疾病。随着糖尿病发病人数的逐年增加,其发病人群也呈现出年轻化趋势。因此,深入开展糖尿病研究工作迫在眉睫。近年来,代谢组学在糖尿病的生物标记物发现、发病机制探索、早期诊断及预后、药物疗效评价等方面的研究中取得了可喜的进展。但限于代谢组学技术的发展局限及糖尿病研究的复杂性,糖尿病的代谢组学研究仍然面临诸多的挑战。本文主要针对代谢组学在糖尿病中的研究进展及其发展方向进行合理的总结和展望。
Diabetes is a metabolic disease with an extremely high incidence in China.In parallel with an increased incidence yearly,the population of diabetes is showing a trend towards younger age.Therefore,it is urgent to carry out research on diabetes in order to develop strategy for prevention.In recent years,metabolomics has made significant progress in the study of biomarkers,pathogenesis,early diagnosis and prognosis,and evaluation of drug efficacy in diabetes.However,limited by metabolomics technology and the complexity of diabetes research,metabolomics in the diabetes research remains challenging.We summarize the progress and prospect the future development of metabolomics in the diabetes research.
作者
李信
马海燕
李鲁盼
孙珊珊
朱丽君
刘玉峰
LI Xin;MA Hai-yan;LI Lu-pan;SUN Shan-shan;ZHU Li-jun;LIU Yu-feng(College of Pharmacy,Liaoning University,Shenyang 110036,China)
出处
《药学学报》
CAS
CSCD
北大核心
2019年第5期828-837,共10页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81403177)
辽宁省高等学校创新人才支持计划(LR2018047)
