摘要
目的探讨ER、PR及HER-2癌基因蛋白在乳腺癌原发灶及复发灶中的表达差异及其临床意义。方法采用免疫组织化学,检测30例乳腺癌原发灶及复发灶中ER、PR及HER2表达。结果 30例复发性乳腺癌患者中,ER由阳性转为阴性率为66.7%(n=12),阴性转为阳性率为41.7%(n=5),总的变化率为56.7%(17/30);PR由阳性转为阴性率为68.8%(n=11),阴性转为阳性率为28.6%(n=4),PR总的变化率为50.0%(15/30);HER-2由阳性转为阴性率为25.0%(n=2),阴性转为阳性率为13.3%(n=4),HER-2总的变化率为20.0%(n=6)。结论 ER、PR及HER-2癌基因蛋白在乳腺癌原发灶和复发灶中的表达存在差异。
Objective To study discordance and significance of ER ,PR,and HER-2 status between primary and recur-rence lesions of breast cancer .Methods Immunohistochemistry assay was used to detect expression of ER ,PR,and HER-2 in primary and recurrence lesions of 30 cases of breast cancer .Results Among 30 patients with recurrent breast cancer ,ER positive to negative rate was 66.7%(n=12),negative to positive rate was 41.7%(n=5),total change rate was 56.7%(17/30);PR. positive to negative rate was 68.8 %(n=11),negative to positive rate was 28.6% (n=4),PR total change rate was 50.0%(15/30);HER-2 positive to negative rate was 25.0%(n=2),negative to positive rate was 13.3%(n=4),HER-2 total change rate was 20.0%(n=6).Conclusion Expression of ER,PR,and HER between primary and recurrence lesions of breast cancer are different .
出处
《实用癌症杂志》
2014年第11期1369-1371,1389,共4页
The Practical Journal of Cancer
基金
江西省卫生厅课题(编号:20093099)
