摘要
目的:通过对根治或改良根治术后浸润性导管癌出现骨转移的乳腺癌患者的临床资料进行回顾性分析,初步探讨影响其骨转移的因素。方法:收集2000～2008年在我院进行治疗乳腺癌病人的临床资料,通过电话随访、门诊复查,完成347例随访,从中选择经过根治术或改良根治术后、病理诊断为浸润性导管癌、骨转移的乳腺癌患者67人,单因素分析67例乳腺癌患者的临床特征(年龄、核分级、肿块大小、淋巴结转移、分期等)。并将单因素分析中有统计学意义的因素进行多因素分析。结果:浸润性导管癌术后患者发生骨转移集中在3年内,患者3年复发转移率为64.18%,单因素分析结果显示年龄,核分级,肿块大小,淋巴转移数目,病理分期,雌激素受体(ER),Her-2受体状态及放疗化疗均对术后发生骨转移有影响(P<0.05)。将单因素分析中显著统计学意义的影响因素再次进行多因素分析,结果显示:肿块大小,淋巴结转移的数目,术后是否完成辅助化疗放疗及Her-2受体情况是影响乳腺癌术后骨转移的重要因素。结论:对初诊乳腺癌患者,做到早期发现、早期诊断、早期治疗,对于预后是十分重要的,对具有转移高危因素的乳腺癌患者早期进行预防性治疗,预防其发生转移,提高患者的生存率,改善生活质量,获得更好的预后。
Objective： To discuss factors which influence on infiltrating ductal breast cancer patiants who were bone metastasised after mastectomy. Methods： The clinical data of infiltrating ductal breast cancer patients who underwent treatment in our hospital from 2000 to 2008 was collected, completely follow-up of 347 cases by telephone and out-patient review, choosing after 67 cases with mastectomy and bone-metastasis were collected for analysis. Result：Bone metastasis always occurred in the first 1-3 years after masteetomy. The rate of bone metastasis of breast cancer was 64. 18%. The univariate analysis revealed that： age, TMN stage, the size of tumor, the number of axillary metastatic lymph node, whether finished radiochemotherapy and the state of ER and Her-2 all influenced on infiltrating ductal breast cancer patiants with bone metastasised after mastectomy. The factors which were more significient （P 〈0.01） were chosen and multivariate Logistic analysis was done. It revealed： the size of tumor, the number of axillary metastatic lymph node, whether finished radiochemotherapy and the state of ER were the most important risk factors. Conclusion： The bone metastasis after operation for infiltrating ductal breast cancer is significantly related with primary lesion diameter, the number of axillary metastatic lymph node and postoperative radiochemotherapy. Early being found, diagnosis, treatment, and finishing postoperative radio chemotherapy may efficiently decrease the rate of local recurrence. Following-up regularly will be beneficial.
出处
《新疆医科大学学报》
CAS
2009年第4期457-459,共3页
Journal of Xinjiang Medical University
关键词
乳腺癌
局部复发
骨转移
breast cancer
local recurrence
bone metastasis
