摘要
抑郁症是临床上常见的精神疾病.目前缺少治疗抑郁症的有效手段.催产素(oxytocin,OT)是一种由下丘脑室旁核和视上核神经元分泌的神经肽,参与生理和病理状态下多种复杂神经精神活动.近年来,许多临床和基础研究显示OT可通过多种机制减轻抑郁症状.本文就OT的生理作用,抑郁状态下OT分泌水平,OT对抑郁相关激素、脑区、环路和神经可塑性及OT对氧化应激反应的作用等最新研究进展做一综述,探究OT减轻抑郁症状的机制.
Depression is a common mental illness.Currently,there is no effective way to treat depression.Oxytocin(OT)is a neuropeptide secreted by the paraventricular nucleus and the supraoptic nucleus neurons in the hypothalamus.OT is involved in a variety of complex neuropsychiatric activities under physiological and pathological conditions.In recent years,many clinical and basic studies have shown that OT can relieve depressive symptoms through multiple mechanisms.This article reviews the research progress of the physiological role of OT,the level of OT secretion in depression,the effect of OT on depression-related hormones,brain regions,neural plasticity and oxidative stress.Our review highlights the potential administration of OT in the treatment of depression.
作者
胡倩瑜
胡灵洁
揭君津
沈思宏
陈晓薇
HU Qian-Yu;HU Ling-Jie;JIE Jun-Jin;SHEN Si-Hong;CHEN Xiao-Wei(The Medical School of Ningbo University,Ningbo Key Laboratory of Behavioral Neuroscience,Zhejiang Provincial Key Laboratory of Pathophysiology,Ningbo 315211,China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2019年第5期456-464,共9页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金(81671089)
浙江省自然科学基金(LY19H090004)
宁波市生命健康科技创新团队–重大精神疾病转化医学(2015C110026)
浙江省病理生理学技术研究重点实验室开放基金(201808)
宁波市自然科学基金(2018A610304)
宁波大学王宽诚幸福基金资助项目~~
