摘要
人乳寡糖(human milk oligosaccharides, HMOs)作为母乳中含量占比第三的固体营养成分, 在婴幼儿早期生长发育中发挥重要作用, HMOs不仅参与免疫系统的发育、维持炎症平衡、调节肠道菌群、参与消化系统的成熟, 还参与大脑神经系统的完善以及学习、记忆功能等高级认知功能的发育。但HMOs在调控神经发育过程中扮演怎样的角色尚不清楚。近年来, 相关研究集中于菌群-肠-脑轴的作用机制, 提示肠-脑之间存在切实的互作方式。HMOs通过这一机制参与儿童神经认知及疾病的生物学进程的研究也有较多报道。本文综述了HMOs的结构特征、种属特异性, 并从菌群-肠-脑轴视角出发浅析HMOs在婴幼儿神经系统发育中的潜在作用路径。
Human milk oligosaccharides(HMOs),as the third most abundant solid nutrient in breast milk,are critical for early infants growth.HMOs are not only involved in the development of the immune system,maintaining inflammation balance,regulating gut microbiota,and participating in the maturation of the digestive system,but also in the improvement of the brain's nervous system and the development of advanced cognitive functions such as learning and memory.However,the role of HMOs in regulating neural development remains unclear.Related studies have focused on the mechanism of the microbiota-gut-brain axis,indicating that there is a practical interaction between the gut and brain.The function of HMOs in children's neurocognition and the biological process of disorders via this mechanism has also been preliminary reported.This review aims to review the structural characteristics and species-specific characteristics of HMOs,and analyze the potential pathways of HMOs in infant nervous system development from the perspective of the microbiota-gut-brain axis.
作者
董佳敏
杨心怡
莫锦灵
张琴芬
张雯婷
Dong Jiamin;Yang Xinyi;Mo Jinling;Zhang Qinfen;Zhang Wenting(Central Laboratory of Pediatrics,Changzhou Children's Hospital Afiliated to Nantong University,Changzhou 213003,China;Children's Health Research Center,Changzhou Children's Hospital Affiliated to Nantong University,Changzhou 213003,China;Pharmaceutical Laboratory,Asthma and Bronchitis Research Center of Changzhou,Changzhou 213003,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2024年第10期920-925,共6页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金(81801493)
国家科技部科技创新2030——"脑科学与类脑研究"重大项目(2021ZD0200515)
中国博士后科学基金(2021M700546)
常州市科技计划(社会发展支撑)(CE20235066)
南京医科大学常州医学中心重点项目(CMCM202314)
南通大学临床研究专项(2019LY029)。
关键词
人乳寡糖
神经发育
认知功能
肠-脑轴
婴幼儿
Human milk oligosaccharides
Neurodevelopment
Cognition
Gut-brain axis
Infants
