摘要
目的探索不同喂养方式、情绪状态与母亲哺喂过程中唾液催产素(oxytocin,OT)水平之间的关系。方法于2019年1—12月在我国重庆、柳州、大连、杭州4所妇幼保健院进行招募,纳入153对3月龄婴儿及其母亲。在母亲给婴儿喂养的前5 min、喂养中5 min和喂养后10 min,分别采集母亲的唾液样本。使用爱丁堡产后抑郁量表(Edinburgh postnatal depression scale,EPDS)评估母亲情绪状态,依据喂养方式分为纯母乳喂养组和人工喂养组。通过酶联免疫试剂盒进行唾液催产素的ELISA测定,使用线性内插法对3个时点测量的OT水平进行转换。以相对于地面的曲线下面积(area under the curve with respect to ground,OTAUCG)表示母亲喂养期间的唾液OT总浓度。采用SPSS 25.0统计软件进行分析,使用双因素方差分析、多元线性回归分析用于探讨不同喂样方式、情绪状态与母亲哺喂过程中唾液OT水平之间的关系。结果喂养方式与母亲情绪交互作用不显著(F=2.440,P=0.120),母亲情绪主效应不显著(F=0.380,P=0.539),喂养方式主效应显著(F=3.350,P=0.021)。进一步分析显示,纯母乳喂养下的OTAUCG[(151561.47±75738.11)pg/mL]高于人工喂养[(122269.03±65029.88)pg/mL],差异有统计学意义(P=0.02);情绪正常母亲的OTAUCG水平[(146106.37±75106.76)pg/mL]与抑郁情绪母亲的OTAUCG水平[(129079.56±67565.87)pg/mL]差异无统计学意义(P=0.221)。多元逐步回归分析显示,相对于纯母乳喂养,人工喂养对母亲唾液OT水平有负向预测作用(β=-0.211,t=-2.513,P=0.013)。结论喂养方式是母亲唾液OT水平的影响因素,纯母乳喂养有助于提高母亲OT水平。
Objective To explore the association between different feeding patterns,emotional states,and salivary oxytocin(OT)levels during breastfeeding.Methods From January to December 2019,153 pairs of 3-month-old infants and their mothers were recruited from 4 maternal and child health hospitals in Chongqing,Liuzhou,Dalian and Hangzhou in China.Saliva samples were collected from the mothers at the first 5 minutes of feeding,5 minutes during feeding,and 10 minutes after feeding.Edinburgh postnatal depression scale(EPDS)was used to evaluate maternal depression.Infants were divided into exclusive breastfeeding group and artificial feeding group according to feeding patterns.ELISA of salivary oxytocin was performed by ELISA kits,and the OT levels measured at the 3 time points were converted using linear interpolation.Area under the curve with respect to ground(OTAUCG)was used to represent the total concentration of salivary OT during the mother's breastfeeding.SPSS 25.0 software was used for statistical analysis.Multiple linear regression analysis and two factors analysis of variance were used to explore the association between different feeding methods,emotional state and salivary oxytocin during breastfeeding.Results The results of the two factors analysis of variance showed that the interaction between feeding pattern and mother's emotion was not significant(F=2.440,P=0.120),the main effect of mother's emotion was not significant(F=0.380,P=0.539),and the main effect of feeding style was significant(F=3.350,P=0.021).The level of OTAUCG under pure breastfeeding((151561.47±75738.11)pg/mL)was higher than that under artificial feeding((122269.03±65029.88)pg/mL),and the difference was statistically significant(P=0.02).There was no statistically significant difference in OTAUCG levels between mothers with normal emotions((146106.37±75106.76)pg/mL)and mothers with depressed emotions((129079.56±67565.87)pg/mL)(P=0.221).Multiple stepwise regression analysis showed that artificial feeding had a negative predictive effect on mate
作者
张小甜
张悦
孙瑾
曾婷
周子琦
沈施芳
徐韬
Zhang Xiaotian;Zhang Yue;Sun Jin;Zeng Ting;Zhou Ziqi;Shen Shifang;Xu Tao(National Center for Women and Children's Health,China CDC,Beijing 100081,China;Dalian Women and Children's Medical Group,Dalian 116021,China;Liuzhou Maternal and Child Health Hospital,Liuzhou 545001,China;Chongqing Maternal and Child Health Hospital,Chongqing 400010,China;Hangzhou Women's Hospital,Hangzhou 310008,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2023年第8期694-699,共6页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金(81803249)。
关键词
催产素
唾液
喂养方式
抑郁情绪
Oxytocin
Salivary
Feeding patterns
Depressive mood
