摘要
目的分析鼻舒适片与地氯雷他定用于过敏性鼻炎治疗中的临床疗效和安全性。方法选取我院2015年8月至2017年8月收治的过敏性鼻炎患者300例,根据治疗方法不同分为对照组和观察组。对照组患者采用口服地氯雷他定治疗,观察组患者口服地氯雷他定+鼻舒适片治疗,分析两组患者治疗后的临床效果。结果观察组患者总有效率为94. 67%,对照组为85. 33%,观察组患者总有效率高于对照组,差异有统计学意义(P<0. 05)。治疗前,两组患者鼻腔通气面积、鼻腔纤毛运动速率、NF-κB、VCAM-1、TGF-α、IL-4、Ig E水平比较,差异无统计学意义(P>0. 05)。治疗后,观察组患者鼻腔通气面积、鼻腔纤毛运动速率高于对照组,NF-κB、VCAM-1、TGF-α、IL-4、Ig E水平低于对照组,差异有统计学意义(P<0. 05)。患者不良反应观察组为4. 67%,对照组为5. 33%,两组不良反应率比较,差异无统计学意义(P>0. 05)。结论鼻舒适片与地氯雷他定联合用于过敏性鼻炎疗效显著,可改善鼻腔纤毛运动速率。降低NF-κB、VCAM-1、TGF-α水平,且不增加不良反应率,安全性较高。
Objective To evaluate the clinical efficacy and safety of Bishushi tablets and desloratadine in the treatment of allergic rhinitis.Methods Total of 300 patients with allergic rhinitis admitted to our hospital from August 2015 to August 2017 were divided into control group and observation group according to different treatment methods.Patients in the control group were treated with oral desloratadine,while patients in the observation group were treated with oral loratadine+Bishushi tablets.Afterward,clinical treatment effects of the two groups were analyzed.Results Total effective rate was 94.67%in the observation group and 85.33%in the control group.Total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,nasal ventilation area,nasal ciliary movement rate,levels of NF-κB,VCAM-1,TGF-α,IL-4 and Ig E were not significantly different between the two groups(P>0.05).After treatment,nasal ventilation area and nasal ciliary movement rate of the observation group were higher than those of the control group,and the levels of NF-κB,VCAM-1,TGF-α,IL-4,Ig E were lower than those of control group,with statistically significant difference(P<0.05).The incidence of adverse reaction was 4.67%in the observation group,and 5.33%in the control group,without statistically significant difference(P>0.05).Conclusion Bishushi tablets combined with desloratadine are effective in the treatment of allergic rhinitis and can improve the rate of nasal ciliary movement and decrease the levels of NF-κB,VCAM-1 and TGF-α,and the incidence of adverse reaction was not increased compared with control group,showing the relatively high safety of the treatments.
作者
陈伟东
江远仕
陈巧霞
Chen Weidong;Jiang Yuanshi;Chen Qiaoxia(Department of Otorhinolaryngology Head and Neck Surgery,People's Hospital of Chenghai District,Shantou,Guangdong515800;Department of Otorhinolaryngology Head and Neck Surgery,Second Affiliated Hospitalof Medical College of Shantou University,Shantou,Guangdong515800,China)
出处
《四川医学》
CAS
2019年第9期931-934,共4页
Sichuan Medical Journal
