摘要
目的探讨单次尿C肽/肌酐比重(UCPCR)在评估2型糖尿病(T2DM)患者胰岛β细胞功能中的应用。方法通过分别测定T2DM患者和健康对照人群的尿C肽、肌酐、空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹血C肽、餐后2 h血C肽、24 h尿C肽,分析UCPCR与上述指标的相关性。结果 T2DM患者UCPCR较对照组明显降低(P <0. 05)。2型糖尿病UCPCR与空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹C肽、2 h血C肽、24 h尿C肽(r=-0. 261,r=-0. 372,r=-0. 492,r=0. 358,r=0. 675,r=0. 583; P <0. 05)有显著相关性。结论尿C肽/肌酐比值可用于评估T2DM患者胰岛β细胞功能。
Objective To explore the application of single urinary C-peptide/creatinine ratio( UCPCR) in assessing the function of islet beta cells in patients with type 2 diabetes( T2DM). Methods Urinary C-peptide,urinary creatinine,fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,fasting blood C-peptide,2-hour postprandial blood C-peptide and 24-hour urinary C-peptide were measured in patients with T2DM and healthy controls respectively. The correlation between UCPCR and fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,fasting blood C-peptide,2-hour postprandial blood C-peptide and 24-hour urinary C-peptide was analyzed. Results UCPCR in diabetic mellitus was significantly lower compared with control group( P < 0. 05). UCPCR in patients with T2DM had significant correlation with fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,fasting C-Peptide and plasma 2 hours C-Peptide,and 24-hour urinary C-peptide( r =-0. 261,r =-0. 372,r =-0. 492,r = 0. 358,r = 0. 675,r = 0. 583;P < 0. 05). Conclusion Urine C-peptide/creatinine ratio can be used to assess islet β-cell function in patients with T2DM.
作者
宋昕倢
叶山东
周婉
邢燕
陈燕
张一鸣
Song Xinjie;Ye Shandong;Zhou Wan;Xing Yan;Chen Yan;Zhang Yiming(Department of Endocrinology,Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001,China)
出处
《中国临床保健杂志》
CAS
2019年第2期193-195,共3页
Chinese Journal of Clinical Healthcare
基金
国家自然科学基金(81800713)
中央引导地方科技创新专项(2017070802D147)
安徽省自然科学基金(1808085QH292)
关键词
糖尿病
2型
C肽
血糖
Diabetes mellitus,type 2
C-peptide
Blood glucose
