摘要
目的 :研究观察甲氨蝶呤治疗寻常型银屑病的疗效以及对Th17细胞相关转导因子的影响。方法 :选择确诊为寻常型银屑病的患者80例,随机分为观察组和对照组,各组均为40例,观察组予以甲氨蝶呤5~15 mg/周,对照组予以阿维A0.5~0.65mg/(kg·d),均规律服药12周,治疗前和治疗后对进行PASI评分评价疗效,采用亲和素-生物素过氧化物酶复合物酶联免疫吸附试验(ABC-ELISA)分别测量观察组治疗前和治疗后血清中的IL-17,IL-23,IL-16含量。结果 :观察组治疗有效率明显高于对照组,前者有效率为92.5%,后者有效率为60%;观察组主要不良反应为胃肠道反应,对照组主要不良反应为头痛、口干、口唇炎、瘙痒等,停药后均能恢复正常。治疗后血清中IL-17,IL-23,IL-16含量低于治疗前。结论 :甲氨蝶呤在寻常型银屑病的治疗效果好,毒副作用少,值得推广,治疗后能够降低Th17细胞相关转导因子的含量。
Objective Observe the treatment of methotrexate in the treatment of psoriasis vulgaris and the effect on Th17 cell transduction factor. Methods Choose 80 cases of psoriasis vulgaris patients, randomly divided into observation group and control group, each group had 40 cases. Observation group were given methotrexate 5~15 mg/weeks, the control group was treated with Etretin0.5~0.65 mg/(kg·d)-1, Regular medication for 12 weeks. Before and after the treatment, evaluate the PASI. Using the avidin biotin peroxidase complex enzyme linked immunosorbent assay(ABC-ELISA)to measure the IL-17, IL-23, IL-16 content of the theobservation group’s serum before and after treatment. Results The effective rate of the observation group(92.5%) is significantly higher than the control group(60%), the main adverse of the observation group reactions are gastrointestinal reaction, and the control group are headache, thirst, cheilitis, pruritus. after stopping drug can resume. After treatment, the serum levels of IL-17, IL-23, IL-16 was lower than that before treatment. Conclusion methotrexate treat psoriasis vulgaris with a good effect, less side effects, is worthy of promotion, Th17 cell transduction factor content after treatment can reduce.
出处
《湖南师范大学学报（医学版）》
2015年第1期119-121,共3页
Journal of Hunan Normal University(Medical Sciences)
