摘要
目的:观察甲氨蝶呤治疗银屑病性关节炎的疗效及不良反应。方法:选符合标准的该病患者59例,随机分为两组。治疗组予甲氨蝶呤治疗,对照组仅用维A酸类药物外用。结果:治疗组治愈ll例,显效9例,好转8例,无效4例,总有效率为87.5%(95%CI=65.6～97.8%);对照组治愈2例,显效6例,好转5例,无效14例,总有效率为48.1%(95%CI=29.3～66.9%);两组综合疗效比较(Ⅱ=3.2531,P=0.0015),差异显著。结论:甲氨蝶呤治疗银屑病关节炎的临床疗效明显优于外用维A酸类药物,其收益OR=0.13(95%CI=0.04～0.47),NNT=3(95%CI=1.35～3.54)。
Objective：To observe the curative effect of therapy of Methotrexate on psoriatic arthritis.Method ：59 cases of sick children suffered from psoriatic arthritis were divided into twogroups randomly.ne treatment group Was treated by Methotrexate.anther control group Was treated by topical tretinoin.Result： In the treatment group 11 cases were cured, 9eases were excellent.8 cases were effective and 4 cases were ineffeetive.The total effective rate Was 87.5%（95%CI=65.6-97.8% ）.In the control group 2 eases were cured,6 cases were excellent, 5 cases were effeetiveand 14 eases were ineffective.The total effective rate was 48.1%（95%CI=29.3-66.9% ）. Thedifference between the two groups Was significant （H=3.2531 ,P=0.0015）.Conclusion：ne eurative effect of Methotrexate with on psoriatic arthritis is better than that of topical tretinoin.OR=0.13 （95%CI=0.04-0.47）, NNT=3 （ 95%C 11.35-3.54 ）.
出处
《北方药学》
2012年第7期38-39,共2页
Journal of North Pharmacy
关键词
甲氨蝶呤
银屑病
维A酸类药物
Methotrexate Psoriatic Arthritis Topical tretinoin
