摘要
目的 观察中国版纳微型猪近交系心脏的大体解剖和组织学 ,为转基因猪心和异种移植提供形态学基础。 方法 应用灌注固定对 10头版纳微型猪近交系进行大体形态观察 ,测量心脏径线、心壁厚度、心脏的腔室、心脏大血管直径。使用苏木精 -伊红染色进行组织学观察。结果 版纳微型猪近交系心脏外形、各腔室及内部结构等与人心脏基本匹配 ,但是微型猪奇静脉直接开口于右心房 ;组织学观察微型猪心脏各部分结构组成及其细胞种类与人心脏相似 ,但是心肌闰盘较人的少 ,心室内膜下的蒲肯野氏纤维较人的粗大。结论 从解剖形态学及组织学观察 ,版纳微型猪近交系心脏与人心脏形态和结构相似 ,有成为异种移植供体的可能性。
Objective To observe the heart anatomic and histological structure of the Banna mini pig inbred lined and to provide the morphological data for heart xenotransplantation and breeding transgens pig. Methods Ten Banna mini pigs (12 18 months old) were affused and fixed by common coratid artery. The heart were observed and measured by gross anatomy and histology. Results There were many similarities between the Banna pig heart and the human heart in anatomy and histology. However, the following differences were observed in the Banna pig heart: ①Azygos vein directly drew into right atrium cordis. ②The intercalated disk of cardiac muscle was less than that of human. ③The Purkinje's fibre was bigger than that of human. Conclusion On the morphology and histology, the structure of Banna pig heart is similar to the heart of human being. It is possible that Banna minipig heart becomes organ donors for xenotransplantation
出处
《中国修复重建外科杂志》
CAS
CSCD
2003年第1期69-72,共4页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家自然科学基金资助项目 (39870 393)
