摘要
目的探讨首发广泛性焦虑障碍患者外周血炎性细胞因子IL-1α、IL-6、IL-12、CRP变化与焦虑症状和执行功能的相关性。方法选取我院2016年5月～2017年5月确诊的首发广泛性焦虑障碍患者100例,本院健康对象50例作为对照组。检测血清中炎性细胞因子IL-1α、IL-6、IL-12、CRP的水平,评估焦虑水平、总体焦虑程度和特质焦虑、状态焦虑水平,测定执行功能。结果首发广泛性焦虑障碍组IL-1α、IL-6、IL-12、CRP等炎性细胞因子水平显著高于正常对照组(P<0.05);状态焦虑SAI、特质焦虑TAI与IL-1α、IL-6、IL-12均呈显著正相关;外维转换错误数与外周血IL-1α、IL-6、IL-12、CRP水平呈正相关。结论首发广泛性焦虑障碍患者存在炎性细胞因子和执行功能异常,和总体焦虑程度、状态焦虑及特质焦虑水平呈正相关。
Objective To investigate the relationship between the changes of IL-1 α and IL-12 in peripheral blood of patients with first episode generalized anxiety disorder and their anxiety symptoms and executive function.Methods A total of 100 patients with generalized anxiety disorder diagnosed in our hospital from May 2016 to May2017 were selected,50 health people as the control group. The levels of serum inflammatory cytokines IL-1α,IL-6,IL-12,anxiety,total anxiety and trait anxiety,state anxiety,and executive function were measured. Results The levels of IL-1α,IL-6,IL-12,CRP and other inflammatory cytokines in the first generalized anxiety disorder group were significantly higher than those in the normal control group(P<0.05);State anxiety SAI and trait anxiety TAI were positively correlated with IL-1 alpha,IL-6 and IL-12;There was a positive correlation between the number of external dimension conversion errors and the levels of IL-1 alpha,IL-6,IL-12 and CRP in peripheral blood. Conclusion There was a positive correlation between inflammatory cytokines and executive function abnormalities in the first episode of generalized anxiety disorder and the level of overall anxiety,state anxiety and trait anxiety.
作者
邓越峰
郭珂珂
何瑞东
李振华
DENG Yuefeng;GUO Keke;HE Ruidong(Department of psychology,Anyang People's Hospital,Anyang 455000,China)
出处
《国际精神病学杂志》
2019年第1期60-62,共3页
Journal Of International Psychiatry
