摘要
目的 分析急性上呼吸道感染患儿血清基质细胞衍生因子-1(SDF-1)、趋化因子受体4(CXCR4)水平与疾病转归的关系。方法 选取2021年2月至2023年2月于泸州市妇幼保健院收治的115例急性上呼吸道感染患儿作为研究组,根据疾病转归分为良好组(77例)和不良组(38例)。另选取同期在泸州市妇幼保健院进行体检的105例健康儿童作为对照组。检测所有研究对象血清SDF-1、CXCR4水平。采用受试者工作特征(ROC)曲线评估血清SDF-1、CXCR4对急性上呼吸道感染患儿疾病转归的评估价值,采用多因素Logistic逐步回归分析影响急性上呼吸道感染患儿疾病转归的相关因素。结果 研究组血清SDF-1、CXCR4水平均高于对照组(P<0.05)。良好组血清SDF-1、CXCR4水平均低于不良组(P<0.05)。ROC曲线结果显示,血清SDF-1、CXCR4评估急性上呼吸道感染患儿疾病转归的曲线下面积(AUC)为0.854(95%CI:0.804~0.904)、0.867(95%CI:0.817~0.917),血清SDF-1联合CXCR4评估急性上呼吸道感染患儿疾病转归的AUC为0.924(95%CI:0.874~0.974)。多因素Logistic逐步回归分析结果显示,血清白细胞介素-6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、SDF-1、CXCR4均为影响急性上呼吸道感染患儿疾病转归的因素(P<0.05)。结论 急性上呼吸道感染患儿血清SDF-1、CXCR4水平均升高,且其水平变化与疾病转归密切相关,且二者联合对急性上呼吸道感染患儿的疾病转归具有重要的诊断价值。
Objective To explore the relationship between the levels of serum stromal cell derived factor-1(SDF-1),chemokine receptor 4(CXCR4)and disease outcome in children with acute upper respiratory tract infection.Methods A total of 115 children with acute upper respiratory tract infection admitted to Luzhou Maternal and Child Health Hospital from February 2021 to February 2023 were selected as the study group,and according to the disease outcome,they were divided into good group(77 cases)and poor group(38 cases).Another 105 healthy children who underwent physical examination in Luzhou Maternal and Child Health Hospital were selected as the control group.Serum levels of SDF-1 and CXCR4 in all research objects were detected.Receiver operating characteristic(ROC)curve was used to evaluate the value of serum SDF-1 and CXCR4 in assessing the disease outcome of children with acute upper respiratory tract infection.Multivariate Logistic stepwise regression analysis was conducted to identify the relevant factors affecting the disease outcome of children with acute upper respiratory tract infection.Results Serum levels of SDF-1 and CXCR4 in the study group were higher than those in control group(P<0.05).The levels of serum SDF-1 and CXCR4 in the good group were lower than those in the poor group(P<0.05).ROC curve results showed that the area under the curve(AUC)of serum SDF-1 and CXCR4 to evaluate the disease outcome of children with acute upper respiratory tract infection were 0.854(95%CI:0.804-0.904)and 0.867(95%CI:0.817-0.917).The AUC of serum SDF-1 combined with CXCR4 to evaluate the disease outcome of children with acute upper respiratory tract infection was 0.924(95%CI:0.874-0.974).The results of multivariate Logistic stepwise regression analysis showed that serum interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT),tumor necrosis factor-α(TNF-α),SDF-1,and CXCR4 were all factors affecting the disease outcome of children with acute upper respiratory tract infections(P<0.05).Conclusion Serum levels of SDF-1 and
作者
唐卫东
王宇
卢祥珍
李莉
熊平
TANG Weidong;WANG Yu;LU Xiangzhen;LI Li;XIONG Ping(Department of Clinical Laboratory,Luzhou Maternal and Child Health Hospital(Luzhou Second People′s Hospital),Luzhou,Sichuan 646000,China;Department of Clinical Laboratory,Panzhihua University Affiliated Hospital,Panzhihua,Sichuan 617000,China;Department of Pediatrics,Luzhou Maternal and Child Health Hospital(Luzhou Second People′s Hospital),Luzhou,Sichuan 646000,China;Department of Children′s Health,Luzhou Maternal and Child Health Hospital(Luzhou Second People′s Hospital),Luzhou,Sichuan 646000,China)
出处
《国际检验医学杂志》
CAS
2024年第24期2973-2976,2982,共5页
International Journal of Laboratory Medicine
基金
四川省中药管理局基金课题(2018CY-S-26)。
