摘要
镁基骨植入物是一种用于骨固定或骨修复的新型生物可降解材料。概述了骨植入器械临床需求,镁及其合金作为骨植入物的材料优势,以及镁基骨植入物的体内应用环境。同时,阐述了镁基骨植入物临床应用存在的问题,包括过快的降解速率和生物相容性问题。在此基础上,重点综述了近年来镁基骨植入物表面改性研究进展,按涂层功能分为耐腐蚀涂层(微弧氧化涂层、溶胶-凝胶涂层、水热涂层及低温等离子聚合涂层)、促骨自愈合涂层(骨愈合药物涂层、类骨生物活性物质涂层)、抗菌涂层(金属离子或氧化物涂层、抗菌药物涂层)、自修复涂层(自发式涂层、触发式涂层)及生物免疫性涂层(免疫活性物质涂层)等。针对各种功能的表面改性涂层,分别从制备方法、功能特性、作用机理、实验结果对比等方面进行归纳,并指出其存在的问题。最后,总结了镁基骨植入物表面改性面临的问题,并展望了未来的发展方向。
Due to the unique degradability,excellent biocompatibility and similar density to bone,magnesium and its alloys have become the choice of biodegradable implants for orthopedic clinical applications.In recent years,surface modification technology has been fully developed to endow magnesium-based bone implants with corrosion resistance and biological functions,which is conducive to better responding to the complex clinical application environment.The work aims to review the research progress of surface modification of magnesium-based bone implants in recent years,and briefly discuss the problems and future development directions of various surface modification methods.Firstly,the background information on the clinical demand for bone implants,the performance advantages and limitations of magnesium-based implants,and the in vivo application environment were introduced.On this basis,according to the functional classification,the research progress of surface modification technology of magnesium-based bone implants was mainly described.The preparation methods,functional characteristics and mechanism of action were described respectively,and the existing problems are pointed out.Finally,the future perspectives of surface modification of magnesium-based bone implants are discussed rationally.According to their different functions,the surface modification of magnesium-based bone implants can be divided into corrosion resistant coatings,bone healing coatings,antibacterial coatings,self-healing coatings,and biological immune coatings.Corrosion resistant coatings,including micro-arc oxidation(MAO)coating,sol-gel coating and hydrothermal coating,can provide physical shielding for the substrate to resist the erosion of inorganic ions and organic substances in the bone environment,thereby effectively controlling the degradation rate of the substrate.The bone healing coatings mainly use bone healing drugs and bone-like bioactive substances to promote osteogenesis and inhibit osteoclast activity.The antibacterial coatings mainly
作者
王镔彬
张皓
申孝龙
王海波
杨成
范兴平
杨晓凤
杨宇松
吴邦杰
周清瑞
WANG Binbin;ZHANG Hao;SHEN Xiaolong;WANG Haibo;YANG Cheng;FAN Xingping;YANG Xiaofeng;YANG Yusong;WU Bangjie;ZHOU Qingrui(Vanadium and Titanium College,Panzhihua University,Sichuan Panzhihua 617000,China;Sichuan Provincial Key Laboratory of Comprehensive Utilization of Vanadium and Titanium Resources,Panzhihua University,Sichuan Panzhihua 617000,China;College of Biological and Chemical Engineering,Panzhihua University,Sichuan Panzhihua 617000,China)
出处
《表面技术》
EI
CAS
CSCD
北大核心
2024年第23期61-77,共17页
Surface Technology
基金
国家自然科学基金(52101286)
四川省中央引导地方科技发展专项项目(2023ZYD0115)
国家级大学生创新创业训练计划(202411360008)
攀枝花学院研究生创新计划(y2024024)。
关键词
镁合金
骨植入物
表面改性
生物功能性
magnesium alloys
bone implants
surface modification
biological functionality
