摘要
随着我国人口老龄化和生活水平提高,人们对性能优异的生物医疗器械和植入材料需求剧增。目前,常见医用植入金属或合金的一些性能,如耐蚀性和生物相容性等,往往不能完全满足临床要求,因此有必要对医用金属材料进行表面改性处理。首先,结合水滑石(LDHs)的特点、性质及近年来的发展情况,综述了常见医用载药LDHs进展,提出了载药LDHs在缓释控释、靶向运输和癌症治疗等方面的应用前景,含有元素Mg、Zn的LDHs具有特殊作用。然后,重点总结常见医用可降解金属(镁、锌合金)和不可降解金属(钛合金)表面单一和复合LDHs涂层的制备方法,介绍不同种类LDHs涂层及其优点,着重分析当前不同医用金属表面LDHs涂层所存在的不足和潜在的应用。另外,金属表面LDHs复合涂层多方面性能均强于单一涂层,致密的LDHs涂层通常作为上层涂层可以起到封孔作用。最后,展望了含Zn、Mg元素LDHs在生物医用方向的应用前景,并分析了含Al、Li元素LDHs在生物医用方向发展需要注意之处和受阻的可能原因,为医用金属表面LDHs涂层的发展提供参考。
With the aging of population and the improvement of living standards in China,the demand for biomedical devices and implant materials with high-performance has increased dramatically.At present,some properties of common biomedical implant metals or alloys,such as corrosion resistance and biocompatibility,can not fully meet the actual clinical requirements.Therefore,it is necessary to perform surface modification treatment on biomedical metal materials.First,combined with the characteristics,properties and recent development of LDHs,the progress of common medical drug-loaded LDHs is reviewed,and the prospects of drug-loaded LDHs in sustained and controlled release,targeted delivery and cancer treatment are proposed.It is pointed out that drug-loaded LDHs containing elements Mg and Zn has special functions.Then,the preparation methods of single and composite LDHs coatings on the surface of common medical degradable metals(magnesium,zinc and their alloys)and non-degradable metals(titanium alloys)are summarized,different types of LDHs coatings and their advantages are introduced,and the shortcomings and potential application possibilities of current hydrotalcite coatings on different medical metals are emphatically analyzed.In addition,it is concluded that the performance of the metal surface LDHs composite coating is stronger than a single coating in many aspects,and it is proposed that the dense LDHs coating is usually used as the upper coating to play the role of sealing.Finally,the application prospect of LDHs containing Zn and Mg elements in biomedical direction is prospected,and the possible reasons for the development of LDHs containing Al and Li in biomedical direction are analyzed.It is hoped to provide a reference for the development of LDHs coating on medical metal surface.
作者
李峰
殷正正
张芬
邹玉红
崔蓝月
曾荣昌
LI Feng;YIN Zheng-zheng;ZHANG Fen;ZOU Yu-hong;CUI Lan-yue;ZENG Rong-chang(Light Alloy Corrosion Laboratory,College of Materials Science and Engineering,Shandong University of Science and Technology,Qingdao 266590,China;College of Chemistry and Biological Engineering,Shandong University of Science and Technology,Qingdao 266590,China)
出处
《表面技术》
EI
CAS
CSCD
北大核心
2021年第2期1-12,共12页
Surface Technology
基金
国家自然科学基金(51601108,52071191)
山东省自然科学基金(ZR2020ME011,ZR2020QE009)。
关键词
医用金属
涂层
水滑石
腐蚀
载药
生物相容性
medical metal
coating
LDHs
corrosion
drug loading
biocompatibility
