摘要
Magnesium(Mg) alloys have attracted a wealth of attention in orthopedic fields for their superior mechanical properties, degradability,and excellent biocompatibility. Consistently, to resolve the issues on rapid degradation, more studies are dedicated to the researches on the composition design, preparation and processing, surface modification, the degradation modes of Mg alloys. Nevertheless, the mechanisms by which Mg alloys promote bone healing remain elusive. This review gives an account of specific mechanisms on Mg alloys promoting bone healing from four aspects, immunomodulatory, angiogenesis, osteogenesis and regulation of osteoclast function. We highlight the regulation of Mg alloys on the functional status and interactions of numerous cells that are involved in bone healing, including immune cells, osteogenicrelated cells, osteoclasts, endothelial cells(ECs), nerve cells, etc., and summarize the signaling pathways involved, with the aim to provide the basis and support on future investigation on mechanisms on Mg alloys driving bone regeneration. More importantly, it provides a rationale and a general new basis for the application of Mg alloys in orthopedic fields.
基金
supported by grants from The National Key Research and Development Program of China (No. 2020YFC1107501)
National Natural Science Foundation of China (No. 51971222)
STS program (No. 20201600200042)
Dong Guan Innovative Research Team Program, the Natural Science Foundation of Liaoning Province (2021-BS-103)
the China Postdoctoral Science Foundation Grant (2020M681020)。
