摘要
维持肠道菌群的稳态对保障人体健康具有重要意义.肠道菌群在调节机体功能方面发挥着关键作用,例如消化、新陈代谢、免疫及认知等,这些生理功能通常依赖于肠道菌群的多样性、菌群结构的稳定性与微生态的平衡性.在空间环境中,航天员会受到包括空间辐射在内的诸多特殊环境因素的影响.空间辐射会造成肠道菌群失衡及其代谢产物变化,使肠道屏障功能受损,进一步引起肠道、心血管、脑及肺等多系统病理损伤.本文分析了空间飞行或模拟空间辐射下肠道菌群稳态及其代谢产物的特征性变化,以及辐射效应下肠道菌群与肠道损伤及其他多系统疾病之间的相互影响,为研究空间辐射病理机制及辐射防护措施提供参考.
Maintaining the homeostasis of gut flora is of great significance to protecting human health.Gut flora plays a key role in regulating body functions,such as digestion,metabolism,immunity,and cognition.These physiological functions often depend on the diversity of gut flora,the stability of the bacterial flora structure,and the balance of the microecology.In the outer space,astronauts face many special environmental factors including the space radiation.Space radiation can cause imbalance of gut flora and changes in metabolites,damaging the intestinal barrier function,and further lead to pathological injury to multiple systems such as the intestine,cardiovascular,brain,and lungs.This paper reviews the characteristic changes in gut flora homeostasis and its metabolites under space flight or simulated space radiation,as well as the interaction between gut flora and intestinal damage and other multi-system diseases under radiation effects.It is expected to provide a reference for the further study of the pathological mechanisms upon space radiation and radiation protection measures.
作者
吴竹君
张昕
庞玉笛
邓玉林
王志敏
WU Zhujun;ZHANG Xin;PANG Yudi;DENG Yulin;WANG Zhimin(Advanced Research Institute of Multidisciplinary Sciences,Beijing Institute of Technology,Beijing 100081;School of Medical Technology,Beijing Institute of Technology,Beijing 100081)
出处
《空间科学学报》
CAS
CSCD
北大核心
2024年第5期873-883,共11页
Chinese Journal of Space Science
基金
国家自然科学基金项目(22207010)
北京理工大学青年教师学术启动计划项目(XSQD-202222005)
北京市科协青年人才托举工程项目共同资助。
关键词
空间辐射
肠道菌群
代谢产物
辐射损伤
多系统疾病
Space radiation
Gut flora
Microbial metabolites
Radiation injuries
Multisystem diseases
