摘要
目的 探讨血清趋化因子C-X3-C基元配体1(CX3CL1)、白三烯B4(LTB4)水平与牙列缺失患者口腔种植修复预后的关系。方法 选择2020年7月至2022年6月在该院接受口腔种植修复的牙列缺失患者233例作为观察组,根据术后6个月种植体预后情况,将观察组分为预后优良组与预后不佳组;另选取同期在该院体检的无牙列缺失、缺损的健康受试者233例作为对照组。检测所有受试者血清CX3CL1、LTB4水平;采用Pearson相关分析牙列缺失患者血清CX3CL1水平与LTB4水平的相关性;采用多因素Logistic回归分析影响口腔种植修复预后不佳的影响因素;绘制受试者工作特征(ROC)曲线分析血清CX3CL1、LTB4水平对口腔种植修复后预后不佳的预测价值。结果 观察组血清CX3CL1、LTB4水平均高于对照组(P<0.05)。Pearson相关性分析结果显示,牙列缺失患者血清CX3CL1水平与LTB4水平呈正相关(r=0.518,P<0.05)。本研究中,预后效果良好192例(预后优良组),其余41例作为预后不佳组;预后不佳组患者血清CX3CL1、LTB4水平显著高于预后优良组(P<0.05)。多因素Logistic回归分析结果显示,吸烟及CX3CL1、LTB4水平升高是牙列缺失患者口腔种植修复预后不佳的独立危险因素(P<0.05);ROC曲线分析结果显示,血清CX3CL1、LTB4单独及二者联合预测口腔种植修复后预后不佳的AUC分别为0.778、0.773、0.945。结论 牙列缺失患者血清CX3CL1、LTB4水平升高与口腔种植修复预后不佳密切相关,临床上可用于口腔种植修复后的预后评估。
Objective To investigate the relationship between serum chemokine C-X3-C ligand 1(CX3CL1)and leukotriene B4(LTB4)levels and the prognosis of oral implant restoration in patients with dentition loss.Methods A total of 233 patients with dentition loss who received dental implant restoration in the hospital from July 2020 to June 2022 were selected as the observation group,which were subdivided into the excellent prognosis group and the poor prognosis group according to the prognosis of implants 6 months after surgery,and meanwhile 233 healthy subjects without dentition loss or defects who underwent medical checkups in the hospital were selected as the control group.The serum CX3CL1 and LTB4 levels were detected in all subjects.Pearson′s correlation was used to analyze the correlation between serum CX3CL1 level and LTB4 level in the patients with dentition loss.Multivariate Logistic regression was used to analyze the influencing factors of the poor prognosis of oral implant repair.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum CX3CL1 and LTB4 levels for poor prognosis after oral implant repair.Results The serum CX3CL1 and LTB4 levels in the observation group were higher than those in the control group(P<0.05).The results of Pearson correlation analysis showed that the serum CX3CL1 and LTB4 levels in the observation group were positively correlated(r=0.518,P<0.05).In this study,192 cases had a good prognosis(excellent prognosis group),and the remaining 41 cases served as the poor prognosis group;the serum CX3CL1 and LTB4 levels in the poor prognosis group were significantly higher than those in the excellent prognosis group(P<0.05).Multivariate Logistic regression analysis results showed that smoking and increased CX3CL1,LTB4 levels were independent risk factors for poor prognosis in patients with dental implant repair(P<0.05).ROC curve analysis results showed that the area under the curves of serum CX3CL1 and LTB4 alone and in combination to predict poor prognosis aft
作者
辜义陆
缪克红
杨凤
杨正涛
GU Yilu;MIAO Kehong;YANG Feng;YANG Zhengtao(Department of Stomatology,Zigong First People′s Hospital,Zigong,Sichuan 643000,China)
出处
《检验医学与临床》
CAS
2024年第16期2396-2399,2405,共5页
Laboratory Medicine and Clinic
基金
四川省自贡市科技计划项目(2020ZC03)。
