摘要
目的探讨慢性阻塞性肺疾病(COPD)患者血清肝素结合蛋白(HBP)、白三烯B4(LTB4)的变化与病情及肺功能参数的关系。方法选取我院呼吸内科收治的60例(COPD组)、60例急性发作期COPD患者(AECOPD组)、60例非COPD的志愿者(对照组);检测三组的血清HBP、LTB4,测量COPD组和AECOPD组的一氧化碳弥散量(DECO)、呼气峰值流速(PEF)、第一秒用力呼气容积(FEV1)、用力肺活量(FVC);并观察AECOPD组上述指标在治疗前及治疗1周后的变化。结果 AECOPD组患者的HBP、LTB4水平高于COPD组和对照组(P<0.05);AECOPD组患者的DECO、PEF、FEV1/FVC测定值均低于COPD组,差异具有统计学意义(P<0.05);在治疗1周后,AECOPD组患者的DECO、PEF、FEV1/FVC测定值均显著的提高(P<0.05),患者的HBP、LTB4测定值较治疗前均显著的降低(P<0.05);经线性相关分析法分析,AECOPD患者治疗前的血清HBP、LTB4测定值与DECO、PEF、FEV1/FVC均呈显著的负相关关系(P<0.05)。结论血清HBP、LTB4可在一定程度上反映COPD患者病情及肺功能损伤程度,对于指导临床治疗具有一定的参考价值。
Objective To investigate the relationship between serum heparin-binding protein(HBP)and leukotriene B4(LTB4)in patients with chronic obstructive pulmonary disease(COPD)and their status and pulmonary function parameters.Methods Sixty patients(COPD group),60 patients with acute COPD(AECOPD group),and 60 non-COPD volunteers(control group)were enrolled in our hospital.Three groups of serum HBP and LTB4 were measured and COPD group was measured.Carbon monoxide diffusion capacity(DECO),peak expiratory flow rate(PEF),forced expiratory volume in the first second(FEV1),and forced vital capacity(FVC)in the AECOPD group;and observation of the above indicators in the AECOPD group before treatment and after 1 week of treatment The change.Results The levels of HBP and LTB4 in the AECOPD group were higher than those in the COPD group and the control group(P<0.05).The DECO,PEF,FEV1/in the AECOPD group The measured value of FVC was lower than that of COPD group,the difference was statistically significant(P<0.05).After 1 week of treatment,the DECO,PEF and FEV1/FVC values of AECOPD group were significantly increased(P<0.05).The measured values of HBP and LTB4 were significantly lower than those before treatment(P<0.05).The linear correlation analysis showed that the serum HBP and LTB4 values of AECOPD patients before treatment were significantly negative with DECO,PEF and FEV1/FVC.Correlation(P<0.05).Conclusion Serum HBP and LTB4 can reflect the degree of disease and lung function damage in patients with COPD to a certain extent,which has certain reference value for guiding clinical treatment.
作者
葛姝君
王晓瑜
王丹
GE Shu-jun;WANG Xiao-yu;WANG Dan(Department of Respiratory Medicine,the 967 th Hospial of PLA,Dalian 116041,China)
出处
《中国实验诊断学》
2020年第1期21-24,共4页
Chinese Journal of Laboratory Diagnosis
关键词
慢性阻塞性肺疾病
急性加重期
HBP
LTB4
chronic obstructive pulmonary disease
acute exacerbation
heparin-binding protein
Leukotriene B4
