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孟鲁司特钠联合沙美特罗替卡松治疗支气管哮喘患儿的效果

Effects of Montelukast sodium combined with Salmeterol fluticasone in treatment of children with bronchial asthma
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摘要 目的:观察孟鲁司特钠联合沙美特罗替卡松治疗支气管哮喘患儿的效果。方法:选取2021年5月至2023年5月该院收治的86例支气管哮喘患儿进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各43例。对照组采用沙美特罗替卡松治疗,研究组在对照组基础上联合孟鲁司特钠治疗,比较两组治疗总有效率、治疗前后肺功能指标[第1秒用力呼气容积(FEV_(1))、FEV_(1)/用力肺活量(FVC)、日排痰量]水平、炎性指标[C反应蛋白(CRP)、降钙素原(PCT)、白细胞计数(WBC)]水平和动脉血气分析指标[动脉血二氧化碳分压(PaCO_(2))、动脉血氧饱和度(SaO_(2))]水平。结果:研究组治疗总有效率为95.35%(41/43),高于对照组的79.07%(34/43),差异有统计学意义(P<0.05);治疗后,研究组FEV_(1)、FEV_(1)/FVC水平均高于对照组,日排痰量少于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、PCT、WBC水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,研究组PaCO_(2)水平低于对照组,SaO_(2)水平高于对照组,差异均有统计学意义(P<0.05)。结论:孟鲁司特钠联合沙美特罗替卡松治疗支气管哮喘患儿可改善肺功能指标和动脉血气分析指标水平,降低炎性指标水平,效果优于单纯沙美特罗替卡松治疗。 Objective:To observe effects of Montelukast sodium combined with Salmeterol fluticasone in treatment of children with bronchial asthma.Methods:A prospective study was conducted on 86 children with bronchial asthma admitted to the hospital from May 2021 to May 2023.According to the random number table method,they were divided into control group and study group,43 cases in each group.The control group was treated with Salmeterolfluticasone,while the study group was treated with Montelukast sodium on the basis of that of the control group.The total effective rate of treatment,the levels of lung function indexes[forced expiratory volume in one second(FEV_(1)),FEV_(1)/forced vital capacity(FVC),daily sputum excretion],inflammatory indexes[C-reactive protein(CRP),procalcitonin(PCT),white blood cell count(WBC)]and arterial blood gas analysis indexes[arterial partial pressure of carbon dioxide(PaCO_(2)),arterial oxygen saturation(SaO_(2))]were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the study group was 95.35%(41/43),which was higher than 79.07%(34/43)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FEV_(1) and FEV_(1)/FVC in the study group were higher than those in the control group,the daily sputum volume was less than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,PCT and WBC in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Furter,after the treatment,the PaCO_(2)level of the study group was lower than that of the control group,the SaO_(2)level was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusions:Montelukast sodium combined with Salmeterolfluticasone in the treatment of the children with bronchial asthma can improve
作者 赵旭东 ZHAO Xudong(Department of Pediatrics of Mengzhou Hospital of Traditional Chinese Medicine,Jiaozuo 454750 Henan,China)
出处 《中国民康医学》 2024年第15期76-79,共4页 Medical Journal of Chinese People’s Health
关键词 孟鲁司特钠 沙美特罗替卡松 支气管哮喘 儿童 肺功能 血气分析指标 炎性因子 Montelukast sodium Salmeterol fluticasone Bronchial asthma Children Lung function Blood gas analysis index Inflammatory factor
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