摘要
目的探究补肺活血胶囊联合沙美特罗替卡松治疗老年急性加重期慢性阻塞性肺疾病(AECOPD)的临床疗效。方法选取2020年1月至2022年9月松滋市第二人民医院收治的100例老年AECOPD患者作为研究对象,按照随机数字表法分为对照组与研究组,每组50例。对照组给予沙美特罗替卡松治疗,研究组给予补肺活血胶囊联合沙美特罗替卡松治疗。比较两组临床症状及疗效评分、炎症因子水平、肺功能指标、指脉氧水平、不良反应发生情况及健康状况评分。结果治疗后,研究组改良版英国医学研究委员会呼吸困难问卷(mMRC)、慢性阻塞性肺疾病评估测试(CAT)评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组降钙素原(PCT)、C反应蛋白(CRP)水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)及最大呼气流量(PEF)均大于对照组,指脉氧高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。治疗后,研究组生理机能、生理职能、情感职能、精神健康、生命活力、社会功能、躯体疼痛评分及总分均高于对照组,差异有统计学意义(P<0.05)。结论补肺活血胶囊联合沙美特罗替卡松可有效改善患者肺功能与指脉氧水平,抑制炎症反应。
Objective To study the efficacy of Bufei Huoxue capsule combined with salmeterol ticasone in the treatment of acute exacerbation chronic obstructive pulmonary disease(AECOPD)in the elderly patients.Methods A total of 100 AECOPD elderly patients admitted to the Second People's Hospital of Songzi City from January 2020 to September 2022 were selected as the research subjects,and they were divided into the control group and the study group according to random number table method,with 50 cases in each group.The control group was given salmeterol ticasone treatment,and the study group was given Bufei Huoxue capsule combined with salmeterol ticasone treatment.The clinical symptoms and efficacy scores,inflammatory factor levels,pulmonary function indexes,pulse oxygen levels,adverse reactions and health status scores were compared between the two groups.Results After treatment,the scores of modified British Medical Research Council(mMRC)and chronic obstructive pulmonary disease assessment test(CAT)in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of procalcitonin(PCT)and C-reactive protein(CRP)in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the forced expiratory volume in one second(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF)in the study group were larger than those in the control group,and pulse oxygen levels was higher than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.After treatment,the scores of physiological function,physiological function,emotional function,mental health,vitality,social function,physical pain and total score in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Application of Bufei Huoxue cap
作者
易华
戴腾飞
姜勇
YI Hua;DAI Tengfei;JIANG Yong(Department of Respiratory Medicine,Second People's Hospital of Songzi City,Jingzhou,Hubei,434200,China)
出处
《当代医学》
2024年第11期55-59,共5页
Contemporary Medicine
关键词
慢性阻塞性肺疾病
急性加重期
沙美特罗替卡松
补肺活血胶囊
肺功能
Chronic obstructive pulmonary disease
Acute exacerbation
Salmeterol ticasone
Bufei Huoxue capsule
Pulmonary function
