摘要
目的探究人表皮生长因子受体-2(HER2)及表皮生长因子受体(EGFR)在人乳头瘤病毒(HPV)相关型宫颈腺癌中的表达变化及与临床病理特征的关系。方法选取2016年1月至2023年6月赣州市妇幼保健院的120例HPV相关型宫颈腺癌患者为观察组,同期的40例慢性宫颈炎患者为对照组。比较两组患者的组织HER2及EGFR表达情况,并比较观察组中不同年龄、silva分型、FIGO分期、组织学分级、淋巴结转移情况、脉管累及情况及阴道壁累及情况者的检测结果,采用Spearman相关性分析明确组织HER2及EGFR表达与HPV相关型宫颈腺癌临床病理特征的关系。结果观察组的HER2及EGFR阳性表达率高于对照组,差异有统计学意义(P<0.05)。观察组中不同silva分型、FIGO分期、组织学分级、淋巴结转移、脉管及阴道壁累及情况者的HER2阳性率比较,差异有统计学意义(P<0.05)。观察组中silva分型C型与其他分型、不同FIGO分期、淋巴结转移、脉管及阴道壁累及情况者的EGFR阳性率比较,差异有统计学意义(P<0.05)。相关性分析显示,HPV相关型宫颈腺癌HER2表达与silva分型、FIGO分期、组织学分级、淋巴结转移、脉管及阴道壁累及情况相关(P<0.05)。EGFR表达与silva分型、FIGO分期、淋巴结转移、脉管及阴道壁累及情况相关(P<0.05)。结论HER2及EGFR在HPV相关型宫颈腺癌中呈现高表达状态,且HER2表达与silva分型、FIGO分期、组织学分级、淋巴结转移、脉管及阴道壁累及情况有关,EGFR表达与silva分型、FIGO分期、淋巴结转移、脉管及阴道壁累及情况有关,在本病患者中的检测价值较高。
Objective To explore the expression changes of human epidermal growth factor receptor 2(HER2)and epithe-lial growth factor receptor(EGFR)in human papilloma virus(HPV)related cervical adenocarcinoma and their correlation with clinicopathological characteristics.Methods A total of 120 patients with HPV related cervical adenocarcinoma from January 2016 to June 2023 in Ganzhou Women and Children's Health Care Hospital were selected as the observation group,and 40 patients with chronic cervicitis were selected as the control group.The expression of HER2 and EGFR in the tissues of the two groups were compared,and the test results of patients with different ages,silva classification,FIGO stage,histological grade,lymph node metastasis,vascular involvement and vaginal wall involvement in the observation group were compared.Spearman correlation was used to analyze the relationship between the expression of HER2 and EGFR and the clinicopathological characteristics of HPV related cervical adenocarcinoma.Results The positive expression rates of HER2 and EGFR in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were significant differences in the positive rate of HER2 among different silva classification,FI-GO stage,histological grade,lymph node metastasis,vascular and vaginal wall involvement(P<0.05).There were significant differences in EGFR positive rates between silva type C and other types,different FIGO stages,lymph node metastasis,vas-cular and vaginal wall involvement in the observation group(P<0.05).Correlation analysis showed that the expression of HER2 in HPV related cervical adenocarcinoma was correlated with silva classification,FIGO stage,histological grade,lymph node metastasis,vascular and vaginal wall involvement(P<0.05).EGFR expression was correlated with silva classi-fication,FIGO stage,lymph node metastasis,vascular and vaginal wall involvement(P<0.05).Conclusion HER2 and EGFR are highly expressed in HPV related cervical adenoc
作者
曾繁晟
廖林虹
王茜
苏惠
叶倩倩
黄丽娟
ZENG Fansheng;LIAO Linhong;WANG Qian;SU Hui;YE Qianqian;HUANG Lijuan(Department of Pathology,Ganzhou Women and Children's Health Care Hospital,Jiangxi Province,Ganzhou 341099,China)
出处
《中国当代医药》
CAS
2024年第13期10-14,共5页
China Modern Medicine
基金
江西省卫生健康委科技计划项目(202212326)。
关键词
人表皮生长因子受体-2
表皮生长因子受体
人乳头瘤病毒感染
宫颈腺癌
临床病理特征
Human epidermal growth factor receptor 2
Epithelial growth factor receptor
Human papilloma virus infection
Cervical adenocarcinoma
Clinicopathological characteristics
