摘要
目的探讨中国农村中老年人(≥45岁)睡眠时长对可能肌少症发生风险的影响,以便降低可能肌少症的发生率。方法采用队列研究方法,通过测量握力和重复5次起坐时间判断是否患可能肌少症,以“中国健康与养老追踪调查”2011年和2013年收集到的7075名未发生可能肌少症的中老年人作为基线数据,随访该队列人群至2015年,构建动态队列数据库,采用Cox比例风险模型研究农村中老年人的睡眠时长与其可能肌少症发生风险的关联。结果与睡眠时长为8~<9 h的农村中老年人相比,睡眠时长<6 h、6~<7 h、7~<8 h和≥9 h的中老年人可能肌少症的发生风险分别增加22%(HR=1.22,95%CI:1.07~1.39,P=0.003)、17%(HR=1.17,95%CI:1.01~1.35,P=0.037)、18%(HR=1.18,95%CI:1.02~1.35,P=0.022)和16%(HR=1.16,95%CI:1.02~1.33,P=0.028)。趋势检验结果显示,随着睡眠时间的缩短(<9 h)农村中老年人患可能肌少症的风险升高,存在剂量-反应关系(P<0.001);对于45~<60岁中年人,相较8~<9 h睡眠时长,睡眠时长<6 h、6~<7 h和7~<8 h的中年人可能肌少症的发生风险分别增加21%(HR=1.21,95%CI:1.01~1.46,P=0.041)、23%(HR=1.23,95%CI:1.02~1.48,P=0.033)和30%(HR=1.30,95%CI:1.08~1.56,P=0.005);与8~<9 h睡眠时长相比,女性中老年人睡眠时长<6 h发生可能肌少症的风险增加了27%(HR=1.27,95%CI:1.06~1.52,P=0.010),男性中老年人睡眠时长≥9 h发生可能肌少症的风险增加了21%(HR=1.21,95%CI:1.01~1.46,P=0.045)。结论中国农村中老年人的睡眠时间过短和过长均会增加可能肌少症的发生风险,并且存在年龄差异,优化睡眠时长可以预防肌少症的发生发展。
Objective To explore the effect of sleep duration on the risk of possible sarcopenia in rural middle-aged and elderly adults(≥45 years)in order to reduce the incidence of possible sarcopenia.Methods The cohort study was conducted base on the Chinese health and retirement longitudinal study(CHARLS).Possible sarcopenia was identified by measuring grip strength and five repetitions of sitting-up time.A total of 7075 participants of middle-aged and elderly adults aged≥45 years without possible sarcopenia in 2011 and 2013 were used as baseline data,and were followed up until 2015.Cox proportional risk model was used to explore the association between sleep duration and the risk of possible sarcopenia in rural middle-aged and elderly people.Results Compared to rural middle-aged and elderly adults with sleep duration of 8-<9 hours,those with sleep duration less than 6 hours,6-<7 hours,7-<8 hours and more than 9 hours had an increased risk of possible sarcopenia by 22%(HR=1.22,95%CI:1.07-1.39,P=0.003),17%(HR=1.17,95%CI:1.01-1.35,P=0.037),18%(HR=1.18,95%CI:1.02-1.35,P=0.022)and 16%(HR=1.16,95%CI:1.02-1.33,P=0.028)respectively.Trend test showed that the risk of possible sarcopenia increased with the shortening of sleep time(<9 h),and there was a dose-response relationship(P<0.001).Among participants aged 45-<60 years,compared with sleep duration of 8-<9 hours,the risk of possible sarcopenia with sleep duration less than 6 hours,6-<7 hours and 7-<8 hours was increased by 21%(HR=1.21,95%CI:1.01-1.46,P=0.041),23%(HR=1.23,95%CI:1.02-1.48,P=0.033)and 30%(HR=1.30,95%CI:1.08-1.56,P=0.005),respectively.Compared with sleep duration of 8-<9 hours,short sleep duration(<6 h)was associated with a 27%increased risk of possible sarcopenia in females(HR=1.27,95%CI:1.06-1.52,P=0.010),and long sleep duration(≥9 h)was associated with a 21%increased risk of possible sarcopenia in males(HR=1.21,95%CI:1.01-1.46,P=0.045).Conclusions The shorter and longer sleep duration among rural middle-aged and elderly were associated with an increased
作者
梁博
魏玥
裴丽君
LIANG Bo;WEI Yue;PEI Lijun(Institute of Population Research,Peking University,Beijing 100871,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2024年第3期290-297,共8页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(41871360)
国家重点研发计划(2018YFC1004303)
达能营养中心膳食营养研究与宣教基金(DIC2015-05)。
关键词
可能肌少症
睡眠时长
队列研究
中老年人
农村
Possible sarcopenia
Sleep duration
Cohort study
Middle-aged and elderly adults
Rural
