摘要
目的:探讨血清可溶性E-选择素(sE-sel)、缺氧诱导因子-1α(HIF-1α)、单核细胞趋化蛋白-1(MCP-1)与糖尿病患者白内障超声乳化术(Phaco)后黄斑水肿的关系。方法:选取2021年1月~2023年1月在西安市第四医院行白内障Phaco治疗的糖尿病性白内障患者167例作为糖尿病性白内障组,根据术后3个月是否发生黄斑水肿分为黄斑水肿组35例和无黄斑水肿组132例,另选取同期87名单纯2型糖尿病(T2DM)患者作为T2DM组。采用酶联免疫吸附法检测血清sE-sel、HIF-1α、MCP-1水平。多因素Logistic回归分析影响糖尿病患者白内障Phaco后黄斑水肿的因素,受试者工作特征(ROC)曲线分析血清sE-sel、HIF-1α、MCP-1水平对糖尿病患者白内障Phaco后黄斑水肿的预测价值。结果:糖尿病性白内障组血清sE-sel、HIF-1α、MCP-1水平高于T2DM组(P<0.05)。167例糖尿病性白内障患者白内障Phaco后3个月黄斑水肿发生率20.96%。多因素Logistic回归显示,T2DM病程延长、增殖型糖尿病视网膜病变(DR)和HbA1c、sE-sel、HIF-1α、MCP-1升高为影响糖尿病患者白内障Phaco后黄斑水肿的独立危险因素(P<0.05)。ROC曲线分析显示,血清sE-sel、HIF-1α、MCP-1水平联合预测糖尿病患者白内障Phaco后黄斑水肿的曲线下面积为0.936,大于血清sE-sel、HIF-1α、MCP-1水平单独预测的0.768、0.775、0.773。结论:血清sE-sel、HIF-1α、MCP-1水平升高是影响糖尿病患者白内障Phaco后黄斑水肿的独立危险因素,血清sE-sel、HIF-1α、MCP-1水平联合预测糖尿病患者白内障Phaco后黄斑水肿的价值较高。
Objective:To investigate the relationship between serum soluble E-selectin(sE-sel),hypoxia-inducible factor-1α(HIF-1α),monocyte chemotactic protein-1(MCP-1)and macular edema after cataract phacoemulsification(Phaco)in diabetic patients.Methods:167 diabetic cataract patients who underwent cataract Phaco treatment in the Xi'an Fourth Hospital from January 2021 to January 2023 were selected as diabetic cataract group,patients were divided into macular edema group(35 cases)and non-macular edema group(132 cases)ccording to whether macular edema occurred 3 months after operation,and another 87 patients with simple type 2 diabetes mellitus(T2DM)were selected as T2DM group.The levels of serum sE-sel,HIF-1αand MCP-1 were detected by enzyme-linked immunosorbent assay.The factors affecting macular edema after cataract Phaco in diabetic patients were analyzed by multivariate Logistic regression analysis,the predictive value of serum sE-sel,HIF-1αand MCP-1 levels for macular edema after cataract Phaco in diabetic patients were analyzed by receiver operating characteristic(ROC)curve.Results:The levels of serum sE-sel,HIF-1αand MCP-1 in diabetic cataract group were higher than those in T2DM group(P<0.05).The incidence of macular edema in 167 patients with diabetic cataract was 20.96%in 3 months after cataract Phaco.Multivariate logistic regression showed that,prolonged course of T2DM,proliferative diabetic retinopathy(DR)and elevated levels of HbA1c,sE-sel,HIF-1αand MCP-1 were independent risk factors for macular edema after cataract Phaco in diabetic patients(P<0.05).ROC curve analysis showed that,the area under the curve of serum sE-sel,HIF-1αand MCP-1 levels combined to predict macular edema after cataract Phaco in diabetic patients was 0.936,which was greater than 0.768,0.775 and 0.773 predicted by serum sE-sel,HIF-1αand MCP-1 levels alone.Conclusion:The increase of serum sE-sel,HIF-1αand MCP-1 levels are independent risk factors affecting macular edema after cataract Phaco in diabetic patients,the combination of s
作者
吴琼
李妍
党冠星
蒋慧莉
刘洪雷
WU Qiong;LI Yan;DANG Guan-xing;JIANG Hui-i;LIU Hong-eia(Department of Ophthalmology,People's Hospital Affiliated to Northwest University/Xian People's Hospital(Xian Fourth Hospital),Xian,Shaanxi,710004,China)
出处
《现代生物医学进展》
CAS
2023年第24期4746-4750,4775,共6页
Progress in Modern Biomedicine
基金
陕西省重点研发计划项目(2021SF-164)。
