摘要
目的:评估糖尿病患者和非糖尿病患者在行白内障超声乳化手术后,角膜内皮细胞和中央角膜厚度变化。方法:观察于我院行白内障超声乳化吸出联合人工晶状体植入术的年龄相关性白内障患者各100例(100眼),于术前1天、术后1周、1个月、3个月、6个月和1年随访记录其角膜内皮细胞密度(endothelial cell density, ECD)、六角形细胞百分比(percentage of hexagonal cells,PHC)、变异系数(coefficient of variation, CV)和中央角膜厚度(central corneal thickness, CCT)等指标,并对结果进行统计学分析。结果:非糖尿病组在术前各指标无明显差异(P>0.05),术后1年ECD, PHC在两组均下降,CV升高(P<0.05),CCT出现明显波动,糖尿病组在术后一周达到峰值。ECD,CV和PHC在术后各时间点出现明显的组间差异(P<0.05)。结论:白内障超声乳化术后远期内,糖尿病组的角膜内细胞和中央角膜厚度较非糖尿病组发生显著变化。
Objective: Here we intended to investigate the changes in corneal endothelial cells and central corneal thickness after phacoemulsification surgery on the eyes of diabetic and non-diabetic cataract patients. Methods: A total of 200 cataract patients who were scheduled for phacoemulsification surgery and intraocular lens implantation were recruited and divided into 2 categories(100 hundred eyes each group). Changes in endothelial cell density(ECD), coefficient of variation(CV), percentage of hexagonal cells(PHC), central corneal thickness(CCT) were all recorded at preoperative day 1 and postoperative 1 week, 1 month, 3 months, 6 months and 1 year. Results:None of the recorded variables showed any difference between the nondiabetic and diabetic groups before surgery(P>0.05). During the postoperative 1 year, ECD and PHC decreased in both groups(all P<0.05) while CV increased, whereas CCT and fluctuated in both groups significantly(both P<0.05), with the peaks at postoperative 1 week in the diabetic group. The groups differed significantly in ECD, CV and PHC at each time point postoperatively(all P<0.05). Conclusions: The diabetic group had more changes in a long time in corneal endothelial cells and central corneal thickness than the nondiabetic group postoperatively.
作者
殷秀丽
陈卓
付安安
刘冬瑞
宋凡倩
葛红岩
YIN Xiu-li;CHEN Zhuo;FU An-an;LIU Dong-rui;SONG Fan-qian;GE Hong-yan(Department of ophthalmology,The First Affiliated Hospital of Harbin,Harbin,Heilongjiang,150001,China)
出处
《现代生物医学进展》
CAS
2019年第11期2159-2162,2119,共5页
Progress in Modern Biomedicine
基金
黑龙江省教育厅科学技术研究项目(12531416)
关键词
超声乳化手术
糖尿病
内皮细胞密度
中央角膜厚度
Phacoemulsification
Diabetes mellitus
Endothelial cells
Central corneal thickness
