摘要
糖尿病患者可能会出现多种并发症,其中糖尿病视网膜病变是其视力丧失的主要原因,而糖尿病性黄斑水肿(DME)是糖尿病视网膜病变患者视力下降的主要原因。DME的发病机制较为复杂,长期高血糖可诱导晚期糖基化终末产物、蛋白激酶C、氨基己糖途径等多种生化代谢异常,导致血管内皮生长因子、胎盘生长因子、色素上皮衍生因子和白细胞介素6等多种细胞因子紊乱,引起血管内皮细胞、神经胶质细胞等多种细胞的功能异常,破坏血-视网膜屏障,血管内液体漏出,同时细胞间液体回吸收减少,进而发生DME。本文将基于相关研究总结DME的流行病学特征,并从生物化学、分子水平及细胞水平三个层面概述DME的发病机制。
Diabetic patients may have a variety of complications,of which diabetic retinopathy is the leading cause of vision loss.Diabetic macular edema(DME)is the main cause of vision loss in patients with diabetic retinopathy.DME has a relatively complex pathogenesis.Persistent hyperglycemia may result in abnormalities in many biochemical metabolic processes,including advanced glycation end products,protein kinase C and hexosamine pathway,which will then disrupt the expressions of vascular endothelial growth factor,placental growth factor,pigment epithelium-derived factor,Interleukin-6,and other cytokines,cause abnormal functions of vascular endothelial cells,glial cells,and other cells,destroy the blood-retinal barrier,cause intravascular fluid leakage,and reduce interstitial fluid absorption,leading to DME.Based on the relevant studies,this paper reviews the epidemiological features of DME and the pathogenesis of DME at the biochemical,molecular,and cellular levels.
作者
王滨
马华锋
李会
马力兴
WANG Bin;MA Huafeng;LI Hui;MA Lixing(Department of Ophthalmology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)
出处
《眼科新进展》
CAS
北大核心
2023年第8期667-672,共6页
Recent Advances in Ophthalmology
