摘要
目的观察糖尿病性视神经病变的临床表现、眼底血管造影和视野特征.方法对173例321眼0～Ⅴ期糖尿病视网膜病变患者的临床表现、视力、视野、荧光造影等临床资料进行分析.结果 321眼中有视神经病变者共155眼,占48.3%.临床表现多样,轻者无任何症状,重者视力下降明显.眼底检查可有视盘水肿、色淡、充血等多种改变.荧光造影中主要表现为视盘新生血管40眼,占25.8%、视盘充盈缺损21眼,占13.5%、视盘水肿45眼,占29.0%及视盘晚期染色49眼,占31.6%.0期DR患者中,25.9%视神经有异常改变.Ⅰ～Ⅴ期DR患者视神经异常率分别为25.0%,37.5%,43.0%,65.1%,85.1%.结论糖尿病性视神经病变发生率高,临床表现多种多样.糖尿病视网膜病变越严重,发生糖尿病视神经病变的可能性越大,但两者不平行.荧光造影检查对糖尿病视神经病变的早期诊断有重要意义.糖尿病性视神经病变是影响视力和预后的重要因素,应引起眼科医生的高度重视.
Objective To investigate the clinical features, characteristics of FFA and visual field of diabetic optic neuropathy. Methods Clinical data, including visual acuity, clinical manifestations, results of visual field and FFA of 173 patients （321 eyes） with stage 0-V diabetic retinopathy were analyzed. Results Diabetic optic neuropathy has varied clinical manifestations, optic edema, pale, congestion can be found under the ophthalmoscope. Diabetic optic retinopathy were observed in 48.3% （155/321） eyes, whose FFA manifestations include optic ncovascularization （40 eyes, 25.8% ）, optic filling defect （21 eyes, 13.5%）, optic edema （45 eyes, 29.0%） and optic staining （49 eyes, 31.6%）. In 25.9% eyes without clinical DR, abnormal manifestation of the discs could be found. The rate is 25.0%, 37.5%, 43.0%, 65.1%, 85.1% in stage Ⅰ - Ⅴ DR, respectively. Conclusions Diabetic optic neuropathy has high incidence and varied clinical manifestations. THe more severe diabetic retinopathy is, the higher the incidence of diabetic optic neuropathy. But the degrees of the two are not parallel. FFA plays an pivotal role in early diagnosis of BON. BON is an important factor influencing prognosis of visual acuity, which should be paid sufficient attention to.
出处
《中国实用眼科杂志》
CSCD
北大核心
2005年第12期1269-1274,共6页
Chinese Journal of Practical Ophthalmology
基金
国家科技攻关计划
常见老年性眼底疾病防治的研究(国科发技字[2004]330号)
国家自然科学基金糖尿病视网膜病变新生血管差异基因的研究(30471849)资助
