摘要
目的:探讨糖尿病患者视觉诱发电位(patternvisualevokedpotential,P-VEP)中P100潜伏时的变化,以及对糖尿病神经病变的评估意义。方法:从中国医科大学附属第一医院眼科门诊选择年龄在31～60岁的2型糖尿病患者44例,病程>1年,患者经眼科检查证实眼底无明显血管病变,矫正视力>0.7,肌电图检查运动传导速度和感觉传导速度均在正常范围,88只眼的P-VEP中P100潜伏时与正常健康人同年龄组的P-VEP中P100潜伏时进行对比观察。结果:糖尿病患者P100潜伏时犤左眼为(104.7±5.9)ms,右眼(104.8±5.9)ms犦较正常健康人犤左眼为(101.2±3.4)ms,右眼为(101.4±3.7)ms犦延长,差异有非常显著性意义(t=3.7,3.4;P<0.01)。结论:糖尿病患者P-VEP中P100潜伏时比正常健康人延长,糖尿病患者检测P-VEP可及早提示神经病变的发生。
AIM:To investigate changes of P100 latency of pattern visual evoked potential(P VEP) in patients with diabetes mellitus(DM),and explore its value in evaluating the diabetic neuropathy. METHODS:Totally 44 type 2 diabetics,aged 31 to 60 years old,were selected form the Outpatient Ophthalmology Clinic of China Medical University.All the patients had the disease course for more than 1 year and were diagnosed to have no obvious angiopathy in funuds of eyes,corrected visual acuity >0.7,and their motor conduction velocity and sensory conduction velocity were in normal range examined by electromyogram.The P100 latencies of P VEP of the 88 eyes were compared with those of normal controls of the same age. RESULTS:The mean P100 latency in DM patients[(104.7±5.9) ms for left eyes and(104.8±5.9) ms for right eyes] were very significantly prolonged as compared with those in the normal controls [(101.2 ±3.4) ms for left eyes and(101.4±3.7) ms for right eyes](t=3.7,3.4,P< 0.01). CONCLUSION:The latencies of P100 are significantly longer in DM patients than normal controls.P VEP detection can indicate the occurrence of neuropathy earlier in patients with DM.
出处
《中国临床康复》
CSCD
2004年第27期5838-5839,共2页
Chinese Journal of Clinical Rehabilitation
