摘要
目的:探究18 F-氟脱氧葡萄糖(FDG)PET/CT代谢参数及异质性指数(HI)与胃癌临床病理特征之间的关系。方法:回顾性分析74例经病理证实的胃腺癌患者的18 F-FDG PET/CT资料及临床病理资料。测量原发灶最大标准化摄取值(SUVmax)、平均标准摄取值(SUVmean)、肿瘤代谢体积(MTV)、总糖酵解量(TLG)、HI。HI-1为感兴趣区内SUV值的变异系数(CV),HI-2为不同SUVmax阈值下MTV值的线性回归斜率的绝对值。运用Spearman秩相关及Logistic回归分析,评估上述参数与胃癌临床病理特征之间的相关性。结果:标准摄值(SUV)及HI在不同分化程度的胃癌中差异具有统计学意义(P<0.01),分化程度与SUVmax及HI-1均呈中度正相关(r值分别为0.32、0.39,均P<0.05)。含有低黏附细胞成分胃癌的SUV及HI-1均较低(P<0.05)。总糖酵解量(TLG)≥57.5 g为Ⅳ期胃癌的独立危险因素[OR:6.089(1.08,34.33)]。结论:18 F-FDG PET/CT代谢参数及HI可反映部分胃癌临床及病理信息。
Objective:To investigate the relationship between 18 F-FDG PET/CT metabolic parameters and heterogeneity index(HI)and the clinicopathological features of gastric cancer.Methods:The 18 F-FDG PET/CT and clinicopathological data of 74 patients with pathologically confirmed gastric adenocarcinoma were retrospectively analyzed.Maximum standardized uptake value(SUVmax),mean standardized uptake value(SUVmean),tumor metabolic volume(MTV),total glycolysis volume(TLG),and HI were measured in the primary foci.HI-1 was the coefficient of variation(CV)of SUV values within the region of interest,and HI-2 was the absolute value of linear regression slopes of the MTV values at different SUVmax thresholds.Spearman s rank correlation and Logistic regression analysis were used to assess the correlation between the above parameters and clinicopathologic features of gastric cancer.Results:SUV value and HI were significantly different in gastric cancers with different degrees of differentiation(P<0.01),and the degree of differentiation was moderately positively correlated with both SUVmax and HI-1(r=0.32,0.39,all P<0.05).The SUV value and HI-1 were lower in gastric cancers containing low adherent cell components(P<0.05).TLG≥57.5 g was an independent risk factor for stageⅣgastric cancer[OR:6.089(1.08,34.33)].Conclusion:18 F-FDG PET/CT metabolic parameters and HI reflect clinical and pathological information of some gastric cancers.
作者
李响
何健
LI Xiang;HE Jian(Department of Nuclear Medicine,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China)
出处
《东南大学学报（医学版）》
CAS
2024年第1期111-117,共7页
Journal of Southeast University(Medical Science Edition)
