摘要
目的分析总结18F—FDGPET／CT在儿童及青少年淋巴母细胞淋巴瘤／白血病（LL／ALL）中的影像学表现及其分期价值。方法回顾性分析15例LI／ALL初诊患儿（男9例，女6例，年龄1～20岁）的临床资料及18F-FDGPET／CT图像，采用两样本t检验、Mann—Whitney“检验及疋。检验比较不同表型LL／ALL的临床参数、SUVmax及T／B比值，分析计算PET／CT诊断骨髓肿瘤浸润的灵敏度、特异性及准确性。结果15例IL/ALL患儿中，T细胞表型（T—LL／ALL）9例，B细胞表型（B—LI／ALL）6例。T-LI／ALL的中位SUVmax为9．4（3．9—14．3），B—LL／ALL的中位SUVmax为5．7（2．3～8．6），2种表型淋巴瘤的18F．FDG代谢差异无统计学意义（M=14．000，P〉0．05）。结合骨髓活组织检查及影像学表现，9例患儿被确诊淋巴瘤骨髓浸润。将骨髓多灶性FDG浓聚和（或）弥漫性代谢增高作为PET诊断骨髓肿瘤累及的标准，则PET／CT的灵敏度、特异性及准确性分别为8／9、4／6及12／15；若仅将骨髓多灶性FDG浓聚作为诊断标准，则相应指标分别为5／9、6／6及11／15：BMB的相应指标分别为5／9、6／6及11／15。结论18F-FDGPET／CT在不同表型LL／ALL患儿中的影像学表现具有一定特点，与BMB相结合有助于患儿危险分层。
Objective To explore the imaging features and staging lymphoblastic lymphoma/acute lymphoblastic leukemia （LL/ALL） on XSF-FDG PET/CT in children and adolescents. Methods Fifteen consecutive children and adolescents with newly diagnosed LL/ALL （9 males, 6 females, age range： 1-20 years） were included in this retrospective study. Clinic-pathological variables and 18F-FDG PET/CT scans were reviewed. Clinical parameters, SUVmax and T/B ratios of patients with different phenotype LL/ALL were compared using Mann-Whitney u test. The sensitivity, specificity and accuracy of 18F-FDG PET/CT to diagnose bone marrow involvement （BMI） were calculated. Results Nine patients were T-LL/ALL, 6 were B-LL/ALL. The median SUVmax of T-LL/ALL was 9.4 （3.9-14.3）, and that of B-LL/ALL was 5.7 （2.3- 8.6）. No significant difference of SUVmax was observed （ u= 14.000, P〉0.05）. Nine patients were identified to have bone marrow involvement. If muhifocal FDG accumulation and diffuse hypermetabolism in bone mar- row were considered as BMI, the sensitivity, specificity and accuracy for PET/CT to identify BMI was 8/9, 4/6 and 12/15, respectively. If only multifocal FDG accumulation in bone marrow was considered as BMI, the parameters of PET/CT were 5/9, 6/6 and 11/15, respectively. For BMB, the parameters were 5/9, 6/ 6 and 11/15, respectively. Conclusion 18F-FDG PET/CT could help to identify LL/ALL with BMI, especially in patients with a negative BMB.
出处
《中华核医学与分子影像杂志》
CAS
北大核心
2016年第4期304-309,共6页
Chinese Journal of Nuclear Medicine and Molecular Imaging
