摘要
目的探讨人乳头状瘤病毒(HPV)、癌抗原125(CA125)、CA153、CA199联合检测用于诊断宫颈癌的价值。方法选取2014年2月至2018年2月秦皇岛市第一医院诊治的50例经手术病理诊断确诊为宫颈癌的患者作为研究对象。采用分层整群抽样回顾性分析的方法,抽取本院经病理诊断确诊为宫颈癌患者为宫颈癌组,宫颈良性肿瘤患者为良性肿瘤组,抽取同期在本院接受常规体检的健康女性为健康对照组,每组各50例。检测并对比各组血清肿瘤标志物表达及阳性检出率,对比各组HPV各亚型阳性检出率,分析各标志物单独与联合检测用于诊断宫颈癌的价值。结果三组一般资料比较,差异无统计学意义(P>0.05);宫颈癌组HPV16、HPV18、联合检测阳性检出率最高,其次为良性肿瘤组、健康对照组,组间比较,差异具有统计学意义(P<0.05);三组HPV31、HPV58阳性检出率比较,差异均无统计学意义(P>0.05);宫颈癌组患者CA125、CA153、CA199表达最高,其次为良性肿瘤组、健康对照组,组间比较,差异具有统计学意义(P<0.05);宫颈癌组各血清肿瘤标志物阳性检出率最高,其次为良性肿瘤组、健康对照组,组间比较,差异具有统计学意义(P<0.05);HPV16与各血清肿瘤标志物联合检测诊断宫颈癌、良性肿瘤的阳性率分别为94.00%、18.00%;特异度方面,联合检测低于CA199;灵敏度与准确度方面,联合检测明显高于各指标单独检测;差异具有统计学意义(P<0.05)。各指标单独检测与联合检测阳性预测值比较,差异无统计学意义(P>0.05)。结论 HPV与血清肿瘤标志物联合检测用于宫颈癌诊断具有很高的应用价值,联合检测具有一定的临床应用优势,较单独检测灵敏度、准确性更好,值得推广应用。
Objective To explore the value of combined detection of human papillomavirus(HPV), cancer antigen 125(CA125), CA153 and CA199 in the diagnosis of cervical cancer. Methods Based on stratified cluster sampling retrospective analysis, the patients diagnosed as cervical cancer by pathological diagnosis were selected as the cervical cancer group and patients with benign cervical cancer as the benign cancer group;healthy women who had received routine physical examination during the same period were taken as healthy control group, with 50 cases in each group. The level of serum tumor marker expression and the positive detection rate were observed and compared;the positive detection rate of HPV subtypes, the value of each individual marker and combined markers for the diagnosis of cervical cancer was analyzed. Results There were no significant differences in the general data among the three groups(P>0.05). The positive rate of HPV16, HPV18 and combined detection was the highest in the cervical cancer group, followed by the benign tumor group and the control group, with statistically significant difference among the three groups(P<0.05). There was no statistically significant difference in the positive detection rate of HPV31 and HPV58 among the three groups(P>0.05). The level of expression of CA125, CA153 and CA199 was the highest in the cervical cancer group, followed by the benign tumor group and the control group, with statistically significant differences(P<0.05). The positive detection rate of serum tumor markers was the highest in the cervical cancer group, followed by the benign tumor group and the control group, with statistically significant differences(P<0.05). The positive detection rates of HPV16 combined with serum tumor markers in the diagnosis of cervical cancer and benign tumor were 94.00% and 18.00%, respectively. The specificity of combined markers was lower than that of CA199 and the sensitivity and accuracy of the combined detection was significantly higher than that of detection for each individual
作者
印海娟
胡金琎
张林光
张荣业
董涛
YIN Haijuan;HU Jinjin;ZHANG Linguang;ZHANG Rongye;DONG Tao(Physical Examination Center,The First Hospital of Qinhuangdao,Qinhuangdao 066100,Hebei,China)
出处
《中国性科学》
2019年第12期37-40,共4页
Chinese Journal of Human Sexuality
关键词
宫颈癌
灵敏度
准确性
诊断价值
Cervical cancer
Sensitivity
Accuracy
Diagnostic value
