摘要
目的探讨患者HPV感染分型检测及母婴传播的关系研究。方法选取2013年1月至2018年3月如皋市人民医院妇产科收治的120例妊娠合并CIN II/III级患者的临床资料作为研究对象。将这120例患者设为研究组,均实施HPV感染分型检测。另回顾同时间段在医院妇产科产检的120例健康孕妇,记为对照组。统计HPV感染分型检测结果,对比疾病组和健康组母体、围产儿不良妊娠结局发生率,分析影响妊娠合并CIN II/III级患者母体及围产儿不良妊娠结局的危险因素。结果本组患者中共有105例经检测明确有HPV感染,其中高危型、低危型和混合型感染的构成比分别为52.38%、40.95%、6.67%,其中高危型HPV感染中以HPV16、HPV18、HPV58构成比较高,多重感染中以HPV16/18、HPV16/58、HPV18/58构成比较高;低危型HPV感染中以HPV6、HPV11、HPV44构成比较高,多重感染中以HPV6/11构成比较高;混合感染中以HPV6/16、HPV6/11构成比较高;疾病组母体及围产儿不良妊娠结局发生率均低于健康组(P<0.05);CIN III级、年龄>35岁、妊娠期糖尿病、妊娠期高血压、HPV混合感染和HPV高危感染均是母体不良妊娠结局发生的危险因素(OR=6.110、6.945、4.200、5.053、4.797、5.124,P<0.05);母体CIN III级、母体年龄>35岁、母体妊娠期糖尿病、母体妊娠期高血压、分娩孕周<36周、母体合并阴道炎、HPV混合感染和HPV高危感染均是围产儿不良妊娠结局发生的危险因素(OR=4.096、4.323、4.362、4.200、4.362、4.341、4.778、4.836,P<0.05)。结论妊娠合并CIN II/III级患者HPV感染率较高,以HPV高危型感染最为常见,均可增加母体和围产儿不良妊娠结局的风险。
Objective To study the relationship between Human papillomavirus(HPV) typing and mother-to-child transmission in patients with advanced HPV infection. Methods The clinical data of 120 pregnant women with high-grade cervical intraepithelial neoplasia(CIN II/III) in our hospital from January 2016 to March 2018 were retrospectively analyzed. HPV infection typing was performed. The clinical data of 120 healthy pregnant women examined in the obstetrics and gynecology department during the same period were also reviewed and recorded as healthy group. The results of HPV infection typing were analyzed. The incidences of adverse pregnancy outcomes of maternal and perinatal infants between the two groups were compared. The risk factors of adverse pregnancy outcomes were analyzed. Results A total of 105 cases of HPV infection were confirmed. The constituent ratios of high-risk, low-risk and mixed infections were 52.38%, 40.95% and 6.67% respectively. HPV16, HPV18 and HPV58 were the most common high-risk HPV infections, and HPV16/18, HPV16/58 and HPV18/58 were the most common multiple infections. HPV6, HPV11 and HPV44 were the most common among low-risk HPV infections and HPV6/11 were the most common among multiple infections. HPV6/16 and HPV6/11 were relatively high in mixed infection. The adverse pregnancy outcomes of maternal and perinatal infants in the disease group were much higher than those in the healthy group(P<0.05). CIN III, age over 35 years, gestational diabetes mellitus, gestational hypertension, HPV co-infection and high-risk HPV infection were all risk factors for maternal adverse pregnancy outcomes(OR=6.110, 6.945, 4.200, 5.053, 4.797, 5.124, P<0.05). Maternal CIN III, maternal age over 35 years, maternal gestational diabetes mellitus, maternal pregnancy hypertension, gestational age less than 36 weeks, maternal vaginitis, HPV mixed infection and HPV high-risk infection were all risk factors for adverse pregnancy outcomes of perinatal infants(OR = 4.096, 4.323, 4.362, 4.200, 4.362, 4.341, 4.778, 4.836, P<0.
作者
沈建平
王晓梅
朱建芬
SHEN Jianping;WANG Xiaomei;ZHU Jianfen(Department of Obstetrics and Gynecology,Rugao People's Hospital,Nantong 226500,Jiangsu,China;Department of Obstetrics and Gynecology,the Second People's Hospital of Zhangjiagang,Zhangjiagang 215631,Jiangsu,China)
出处
《中国性科学》
2019年第12期121-124,共4页
Chinese Journal of Human Sexuality
关键词
妊娠
高级别宫颈上皮内瘤变
人乳头瘤病毒
分型
Pregnancy
High-grade cervical intraepithelial neoplasia(CIN II/III)
Human papillomavirus(HPV)
Typing
