摘要
目的:探讨红细胞体积分布宽度(Red blood corpuscular volume distribution width,RDW-CV)/血小板比值与胃癌晚期化疗患者复发转移的关系。方法:选取2020年11月至2022年4月于商丘市第四人民医院接受化疗治疗的110例胃癌晚期患者的临床资料进行回顾性研究。根据化疗后6 m内是否复发转移将其分为发生组和未发生组。设计调查表,通过查阅胃癌晚期患者病历和随访资料,收集所有患者年龄、体重、病理类型、原发灶部位、既往手术史等基本资料;收集并对比所有胃癌晚期患者于化疗结束后4 w时血常规、白蛋白、总蛋白、肌酐,并计算RDW-CV/血小板计数(Platelet count,PLT)比值,分析RDW-CV/PLT比值与胃癌晚期化疗患者复发转移的关系。结果:化疗后6 m内,患者发生复发转移的共61例,占比55.45%;发生组PLT水平明显高于未发生组,RDW-CV/PLT水平明显低于未发生组(P<0.05);两组患者年龄、体重、病理类型、原发灶部位等无明显差异(P>0.05);经点二列相关结果显示,PLT与胃癌晚期化疗患者复发转移间呈正相关(r>0,P<0.05),RDW-CV/PLT与复发转移呈负相关(r<0,P<0.05);绘制受试者工作特征(Receiver operating characteristic curve,ROC)曲线,结果显示,RDW-CV/PLT预测胃癌晚期化疗患者复发转移发生情况的曲线下面积(Area Under Curve,AUC)值为0.754,具有一定预测效能。结论:RDW-CV/PLT与胃癌晚期化疗患者复发转移间有关,RDW-CV/PLT值越小,复发转移可能性越大。
Objective:To investigate the relationship between the red blood corpuscular volume distribution width(RDWCV)/platelet ratio and the recurrence and metastasis of patients with advanced gastric cancer after chemotherapy.Methods:The clinical data of 110 patients with advanced gastric cancer who received chemotherapy from the Fourth People’s Hospital of Shangqiu from November 2020 to April 2022 were collected for a retrospective study.They were divided into occurrence group and non-occurrence group according to the recurrence and metastasis within 6 months after chemotherapy.A questionnaire was designed to collect the basic data of all patients,such as age,weight,pathological type,location of primary lesion,and previous operation history,by consulting the medical records and follow-up data of patients with advanced gastric cancer.The blood routine,albumin,total protein and creatinine were collected and compared in all patients with advanced gastric cancer at 4 weeks after chemotherapy.The RDW-CV/platelet count(PLT)value was calculated,and the relationship between RDW-CV/PLT ratio and recurrence and metastasis of patients with advanced gastric cancer chemotherapy was analyzed.Results:In 110 patients with advanced gastric cancer,61 cases(55.45%)had recurrence and metastasis within 6 months after chemotherapy.The level of PLT in the occurrence group was significantly higher than that in the non-occurrence group,and the level of RDW-CV/PLT was significantly lower than that in the non-occurrence group(P<0.05).There was no statistic significant difference between the two groups in age,body weight,pathological type and primary lesion location(P>0.05).The results of point binary correlation showed that PLT was positively correlated with recurrence and metastasis in patients with advanced chemotherapy of gastric cancer(r>0,P<0.05),while RDW-CV/PLT was negatively correlated with recurrence and metastasis(r<0,P<0.05).The subject working characteristic(ROC)curve was drawn.The results showed that the area under the curve(AUC)va
作者
田和鑫
Tian He-xin(Department of Clinical Laboratory,The Fourth People’s Hospital of Shangqiu,Shangqiu 476100,Henan,China)
出处
《四川生理科学杂志》
2024年第1期153-156,共4页
Sichuan Journal of Physiological Sciences
关键词
胃癌
复发转移
红细胞体积分布宽度
血小板
Gastric cancer
Recurrence and metastasis
Red blood corpuscular volume distribution width
Platelet
