摘要
目的：探讨Tensin1蛋白表达水平与胃癌临床病理特征及预后的关系。方法：采用回顾性病例对照研究方法。收集2011年7月31日至2013年12月31日江苏大学附属医院收治的163例胃癌患者的临床病理资料。收集患者的术后胃癌组织和对应癌旁组织病理学标本，石蜡切片包埋，并行免疫组织化学染色检测。观察指标：（1）胃癌组织和癌旁组织中Tensin1蛋白表达情况。（2）胃癌组织中Tensin1蛋白表达与患者临床病理因素的关系。（3）随访和生存情况。（4）胃癌患者的预后因素分析。采用电话方式进行随访，了解患者生存情况。随访时间截至2017年1月1日。偏态分布的计量资料采用M（范围）表示。计数资料采用双侧χ^2或配对χ^2检验。采用KaplanMeier法绘制生存曲线计算生存率，Log-rank检验进行生存分析。单因素及多因素分析采用COX比例风险模型。结果：（1）胃癌组织和癌旁组织中Tensin1蛋白表达情况：免疫组织化学染色检测显示Tensin1蛋白在胃癌组织和癌旁组织细胞中主要表达于细胞质。163例患者，胃癌组织中154例Tensin1蛋白表达阳性（66例高表达、88例低表达），9例表达阴性；癌旁组织中79例Tensin1蛋白表达阳性（37例高表达、42例低表达），84例表达阴性；两者Tensin1蛋白表达阳性比例和表达水平比较，差异均有统计学意义（χ^2=64.65，12.93，P〈0.05）。（2）胃癌组织中Tensin1蛋白表达与患者临床病理因素的关系：胃癌患者术后发生和未发生肿瘤转移患者胃癌组织中Tensin1蛋白高表达率分别为31.34%（21/67）和46.88%（45/96），两者比较，差异有统计学意义（χ^2=3.95，P〈0.05）。（3）随访和生存情况：163例患者术后均获得随访，随访时间为3.3-64.7个月，中位随访时间为28.7个月。66例胃癌组织中Tensin1蛋白高表达患者3年累积无病生存率和累积总体生存率分别为63.12%�
Objective：To investigate the associations between expression of Tensin1 protein and clinicpathological characteristics and prognoses of gastric cancer （GC） patients. Methods：The retrospective casecontrol study was conducted. The clinicopathological data of 163 GC patients who were admitted to the Affiliated Hospital of Jiangsu University between July 31, 2011 and December 31, 2013 were collected. The GC tissues and adjacent normal tissues were taken to paraffin imbedding, and then were detected by immunohistochemistry. Observation indicator： （1） expressions of Tensin1 protein in GC tissues and adjacent normal tissues; （2） association between expression of Tensin1 protein in GC tissues and clinicopathological characteristics; （3） followup and survival situations; （4） prognostic factors analysis. Followup using telephone interview was performed to detect survival up to January 1, 2017. Measurement data with skewed distribution were described as M （range）. Count data were analyzed using the chisquare test or pairing chisquare test. The survival curve and rate were respectively drawn and calculated using the KaplanMeier method, and Log-rank test was used for survival analysis. The univariate analysis and multivariate analysis were done using the COX roportional hazard model. Results：（1） Expressions of Tensin1 protein in GC tissues and adjacent normal tissues： immunohistochemistry showed that Tensin1 protein in GC tissues and adjacent normal tissues mainly expressed in cytoplasm. Of 163 patients, 154 （66 with high expression and 88 with low expression） and 9 had respectively positive and negative expressions of Tensin1 protein in GC tissues; 79 （37 with high expression and 42 with low expression） and 84 had respectively positive and negative expressions of Tensin1 protein in adjacent normal tissues, with statistically significant differences in positive expression ratio and expression levels （χ^2=64.65, 12.93, P〈0.05）. （2） Association between expression of Tensi
作者
曹一鑫
李小琴
王宏宇
任琎
顾汉刚
严玲花
陈文琪
王德强
Cao Yixin;Li Xiaoqin;Wang Hongyu;Ren Jin;Gu Hangang;Yan Linghua;Chen Wenqi;Wang Deqiang(Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China)
出处
《中华消化外科杂志》
CAS
CSCD
北大核心
2018年第6期612-618,共7页
Chinese Journal of Digestive Surgery
基金
国家自然科学基金（81301765、81402485）
江苏省青年医学重点人才项目（QNRC2016829）
镇江市科技计划项目（SH2013079、SH2015054、SH2016038）
关键词
胃肿瘤
Tensin1
临床病理特征
预后
生存率
Gastric neoplasms
Tensinl
Clinicopathological characteristics
Prognosis
Survival rate
