摘要
目的:探究昆海牡甲汤辅助微创旋切术联合重组人源胶原蛋白功能敷料对乳腺良性肿块切除术患者创面止血及凝血功能的影响。方法:选取2019年9月-2021年9月我院收治的乳腺良性肿块患者90例,所有患者均接受乳腺良性肿块麦默通微创旋切术治疗,按照患者的治疗意愿分为观察组和对照组各45例,其中对照组患者术后给予重组人源胶原蛋白功能敷料,观察组患者在对照组基础上给予昆海牡甲汤口服,其他止血及治疗措施与观察组一致,观察记录两组患者的术中出血情况、住院成本及效果比、治疗前后血常规及凝血功能情况。结果:观察组患者的术中出血量、术后出血量、血肿发生率均显著低于对照组,差异有统计学意义(P <0.05);两组患者的住院时间对比未见显著差异(P>0.05),观察组患者的住院成本高于对照组患者(P <0.05),但观察组的有效率及成本效果比显著优于对照组(P <0.05);术前及术后,观察组患者的白细胞计数(WBC)、红细胞计数(RBC)、血红蛋白(HGB)水平均显著低于对照组,血小板(PLT)水平显著高于对照组(P <0.05);两组患者术前及术后凝血功能指标比较,差异无统计学意义(P>0.05)。结论:重组人源胶原蛋白功能敷料联合昆海牡甲汤对乳腺良性肿块切除术患者创面止血具有良好的效果,不会影响患者的凝血功能,具有较好的安全性和治疗成本效果比。
Objective To explore the effects of recombinant human collagen functional dressing combined with Kunhai Mujia decoction on wound hemostasis and coagulation in patients undergoing benign breast mass resection.Methods Ninety patients with benign breast masses admitted to our hospital from September 2019 to September 2021 were selected retrospectively as the subjects of this study.All patients received minimally invasive resection of benign breast masses with Macintosh.They were divided into the observation group and the control group according to their treatment wishes.The patients in the observation group were injected with recombinant human collagen functional dressing 15 minutes before operation and 12 hours after operation combined with Kunhai stag decoction.The patients in the control group were given the same amount of normal saline as a placebo at the same time.Other hemostasis and treatment measures were the same as those in the observation group.The intraoperative bleeding,hospitalization cost and effect ratio,blood routine test before and after treatment and blood coagulation function of the patients in the two groups were observed and recorded.Results The intraoperative blood loss,postoperative blood loss and hematoma occurrence in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).The hospitalization cost of the observation group was higher than that of the control group(P<0.05),but the effective rate and cost-effectiveness ratio of the observation group were significantly better than those of the control group(P<0.05).The levels of WBC,RBC and HGB in the patients were significantly lower than those in the control group,and the level of PLT was significantly higher than that in the control group(P<0.05).Conclusion Recombinant human collagen functional dressing combined with Kunhai Mujia decoction has a good effect on wound hemostasis in patients with benign breast mass resection,without affecting the coagulation functio
作者
单世胜
王华龙
SHAN Shi-sheng;WANG Hua-long(Department of Nail and Breast Surgery,Xianyang Central Hospital,Xianyang,712000,China)
出处
《中国中西医结合外科杂志》
CAS
2024年第1期95-99,共5页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
陕西省教育厅2021年度青年创新团队建设科研计划项目(21JP123)。
关键词
昆海牡甲汤
重组人源胶原蛋白功能敷料
乳房肿块
旋切术
止血
凝血
Kunhai Mujia decoction
recombinant human collagen functional dressing
breast mass
atherectomy
hemostasis
coagulation
