摘要
目的探讨阿替普酶在急诊科急性脑梗死患者溶栓治疗中的临床价值。方法92例急诊科急性脑梗死患者,以治疗模式不同分成常规组和研究组,每组46例。常规组采用常规治疗,研究组在常规治疗基础上加用阿替普酶静脉溶栓治疗。比较两组治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分及Barthel指数评分,临床疗效,不良反应发生情况。结果治疗1周后,研究组NIHSS评分(6.75±1.51)分低于常规组的(10.86±1.62)分,Barthel指数评分(71.00±10.58)分高于常规组的(60.82±10.89)分,差异具有统计学意义(P<0.05)。研究组的治疗总有效率97.83%高于常规组的80.43%,差异具有统计学意义(P<0.05)。研究组不良反应发生率4.35%低于常规组的6.52%,但差异无统计学意义(P>0.05)。结论急诊科急性脑梗死患者应用阿替普酶静脉溶栓治疗,可有效提升患者的治疗效果,改善神经功能缺损情况,提高患者的日常生活能力,具备较高的治疗安全性,值得推广。
Objective To discuss the clinical value of alteplase thrombolysis in patients with acute cerebral infarction in emergency department.Methods A total of 92 patients with acute cerebral infarction in emergency department were divided into conventional group and study group according to different treatment modes,with 46 cases in each group.The conventional group was treated with conventional therapy,and the study group was treated with alteplase intravenous thrombolysis on the basis of conventional therapy.The National Institutes of Health Stroke Scale(NIHSS)score and Barthel index score before and after treatment,clinical efficacy and adverse reactions were compared between the two groups.Results After 1 week of treatment,NIHSS score of(6.75±1.51)points in the study group was lower than that of(10.86±1.62)points in the conventional group,and Barthel index score of(71.00±10.58)points was higher than that of(60.82±10.89)points in the conventional group.The differences were statistically significant(P<0.05).The total effective rate of 97.83%in the study group was higher than that of 80.43%in the conventional group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was 4.35%,which was lower than that of 6.52%in the conventional group,but the difference was not statistically significant(P>0.05).Conclusion The application of alteplase in intravenous thrombolysis of in emergency department can effectively improve the therapeutic effect of patients with acute cerebral infarction,optimize the neurological function and activities of daily living of patients,has higher therapeutic safety,which is worth popularizing.
作者
陈小沛
CHEN Xiao-pei(Department of Emergency,Nanjing Pukou District Central Hospital,Nanjing 210000,China)
出处
《中国实用医药》
2023年第20期91-94,共4页
China Practical Medicine
关键词
阿替普酶
急诊科
急性脑梗死
治疗效果
Alteplase
Emergency department
Acute cerebral infarction
Therapeutic effect
