摘要
目的研究大动脉粥样硬化性(LAA)脑梗死相关血脂指标的性别差异。方法选择中国国家卒中登记数据库中4189例首发脑梗死患者,依据TOAST病因学分型分为LAA组1919例、小血管闭塞(SVO)组716例和非LAA&SVO组1554例。分析TG、TC、HDL-C、LDL-C水平与LAA的相关性。结果 3组除TG外,女性TC、HDL-C、LDL-C水平均高于男性(P<0.01)。LAA组vs非LAA组,LAA组vs非LAA&SVO组的2个logistic回归模型分析均显示:TC、LDL-C水平与LAA发生相关。男性患者TG水平与LAA的相关性有显著意义,TG每升高1个四分位数区间,LAA组较非LAA组、非LAA&SVO组发生的可能性分别增加8.6%和15.0%。结论相较于其他缺血性脑卒中亚型,TC、LDL-C增高与LAA的发生密切相关;TG在预测颅内外LAA风险时,存在性别差异,对于男性除常规关注TC、LDL-C外,还需将TG考虑在内。
ge artery atherosclerosis（LAA） ischemic stroke. Methods A total of 4189 first-ever ischemic stroke patients,selected from China National Stroke Registry, were divded into LAA ischemic stroke group（n=lgl9）, small vessel occlusion（SVO） group（n= 716）, and non-LAA＆SVO group（n-- 1554） according to the TOAST etiological classification. Correlation of serum TG,TC, HDL-C and LDL-C levels with LAA was analyzed. Results The serum TC, HDL-C and LDL-C levels were significantly higher in female LAA ischemic stroke patients than in male LAA ischemic stroke patients（P〈0.01）. Logistic regression analysis showed that the serum TC, HDL-C and LDL-C lev- els were correlated with the occurrence of LAA. The serum TG level was closely correlated with LAA in male patients. Conclusion Elevated serum TC and LDL-C levels are closely correlated with LAA in ischemic stroke patients. There is a gender difference when serum TG level is used as a predictor for the risk of LAA. Besides serum TC and LDL-C levels, serum TG level should thus be considered in male LAA ischemic stroke patients.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2013年第3期268-272,共5页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
国家自然科学基金(81071115)
