摘要
目的分析2020—2021年天津市1型糖尿病(T1DM)儿童糖化血红蛋白(HbA1c)控制状况及影响因素,为1型糖尿病患儿控制血糖提供理论依据。方法选取2020年1月至2021年6月天津市儿童医院收治的T1DM患儿538例,其中男童275例,女童263例,测定所有患儿糖化血红蛋白(HbA1c)水平,根据HbA1c水平分为控制良好组(HbA1c<7.0%,n=469)和控制不佳组(HbA1c≥7.0%,n=69),抽取两组患儿空腹肘静脉血3ml,对比两组HbA1c、FPG、2hPG、TC、LDL-C水平,从病历系统收集患儿临床资料,采用单因素分析和logistic回归分析影响T1DM患儿HbA1c控制情况的影响因素。结果两组一般资料比较,两组在年龄、性别、T1DM病程间差异无统计学意义(P<0.05);控制不佳组HbA1c、FPG、2hPG、TC和LDL-C水平明显高于控制良好组(P<0.05);血糖监测<60次/月(OR=3.017)、未控制饮食(OR=2.871)、肥胖(OR=2.623)是T1DM患儿HbA1c控制不佳的独立危险因素(P<0.05)。结论T1DM患儿HbA1c控制不佳的风险较大,需加强对糖尿病患儿家长宣传教育,定期监测血糖,控制饮食,有效改善患儿血糖控制状况。
Objective To analyze the control status and influencing factors of glycosylated hemoglobin(HbA1c)in children with type 1 diabetes mellitus(T1DM)in Tianjin from 2020 to 2021,and to provide a theoretical basis for controlling blood glucose in children with type 1 diabetes mellitus.Methods A total of 538 children with type 1 diabetes,including 275 males and 263 females,were selected from our hospital from January 2020 to June 2021.All the children were determined according to the level of HbA1c and divided into well-controlled group(HbA1c<7.0%,n=469)and poorly controlled group(HbA1c≥7.0%,n=69),3ml fasting elbow venous blood was extracted from the two groups,and the levels of HbA1c,FPG,2hPG,TC and LDL-C were compared between the two groups.Clinical data of the children were collected from the medical record system.The factors affecting the control of HbA1c in children with type 1 diabetes were analyzed by univariate analysis and logistic regression.Results The comparison of general data between the two groups showed no significant difference in age,sex and course of type 1 diabetes mellitus(P<0.05).The levels of HbA1c,FPG,2hPG,TC and LDL-C in poorly controlled group were significantly higher than those in well controlled group(P<0.05).The blood glucose monitoring<60 times/month(OR=3.017),uncontrolled diet(OR=2.871),obesity(OR=2.623)were independent risk factors for poor control of HbA1c in children with type 1 diabetes(P<0.05).Conclusions Children with type 1 diabetes mellitus have a greater risk of poor control of HbA1c.It is necessary to strengthen publicity and education for parents of children with diabetes,regularly monitor blood glucose and control diet to effectively improve blood glucose control in children.
作者
陈枞
符榕
吕玲
CHEN Cong;FU rong;LYU Ling(Pediatric Endocrinology Department of Tianjin Children's Hospital,Tianjin 300074,China)
出处
《公共卫生与预防医学》
2023年第6期92-94,103,共4页
Journal of Public Health and Preventive Medicine
基金
天津市医学重点学科(专科)建设项目资助(TJYXZDXK-040A)。
关键词
1型糖尿病
糖化血红蛋白
控制状况
Type 1 diabetes mellitus
Glycosylated hemoglobin
Control the situation
