摘要
2型糖尿病(type 2 diabetes mellitus,T2DM)是常见慢性病,近年来发病率逐年大幅攀升,对人类健康危害大,是目前公共健康的热点问题之一。2型糖尿病发病的原因及机制的研究受到各个医学领域全方位的重视,研究显示肠道菌群代谢产物与2型糖尿病的发生发展存在紧密关联。肠道菌群细菌代谢产物的检测技术不断创新,近年的研究提示肠道菌群代谢产物在2型糖尿病的预测领域表现出巨大潜力。综述相关研究成果,为建立人肠道菌群的细菌代谢产物预测2型糖尿病风险的模型提供参考。
Type 2 diabetes mellitus(T2DM)is a highly prevalent chronic disease,it is a metabolic disorder characterized by an imbalance in blood glucose level,altered lipid profile and high blood pressure.In recent years,the incidence of T2DM has increased sharply and the age distribution is widespread,which is harmful to human health.Recently,numerous studies aimed to detect the causality between the gut microbial metabolites and T2DM have shown that the gut microbial metabolites were linked with T2DM.And with the rapid development of the detection technology of gut flora and metabolites,recent studies have suggested that intestinal flora metabolites have great potential value in predicting T2DM.This review of the relevant research results provides a reference for establishing a risk prediction model for T2DM suing human gut microbial metabolites.
作者
金小玲
刘晔
李晓迪
高晓莉
韩芳
JIN Xiao-ling;LIU Ye;LI Xiao-di;GAO Xiao-li;HAN Fang(Nutrition Department,General Hospital of Central Theater Command,Wuhan,Hubei 430030,China)
出处
《公共卫生与预防医学》
2022年第6期11-14,共4页
Journal of Public Health and Preventive Medicine
基金
湖北省卫生健康委员会科研项目(WJ2021D003)
不同钠与碘摄入水平与肠道菌群多样性在妊娠高血压疾病发病机制中的研究(1427)。
关键词
2型糖尿病
肠道菌群
代谢产物
Type 2 diabetes mellitus
Gut microbiome
Metabolites
