摘要
目的:探究宫颈鳞癌(SCC)动态增强磁共振成像(DCE-MRI)定量参数与临床病理分级的相关性。方法:回顾性分析2017年5月-2022年7月收治的98例SCC患者资料,均于术前1周内行DCE-MRI检查,术后行肿瘤病理检查,收集患者临床病理参数及DCE-MRI定量参数[容量转移常数(K^(trans)),速率常数K_(ep),血管外细胞外间隙容积比(V_(e))],比较不同临床分期、病理分级及不同淋巴结转移情况下K^(trans)、K_(ep)、V_(e)值,并spearman相关性分析与临床分级的相关性。结果:98例临床T分期Ⅰ期16例、Ⅱ期27例、Ⅲ期31例、Ⅳ期24例,组织分化为低分化33例、中分化41例、高分化24例,淋巴结出现转移26例、未转移72例,肌层浸润深度为浅肌层浸润68例、深肌层浸润30例。K^(trans)、K_(ep)、V_(e),在Ⅰ~Ⅱ期、Ⅲ期、Ⅳ期及病理分级1级、2级、3级患者中均逐渐升高,有淋巴转移患者均高于无淋巴转移患者(均P<0.05);Spearman相关性分析显示,SCC患者DCE-MRI定量参数K^(trans)、K_(ep)、V_(e)与淋巴结转移呈正相关(P<0.05)。结论:宫颈鳞癌DCE-MRI定量参数K^(trans)、K_(ep)、V_(e)值均随临床病理分期、分级增加而升高,且与淋巴结转移存在相关性。
Objective:To explore the correlation between the quantitative parameters of dynamic contrast enhanced magnetic resonance imaging(DCE MRI) of patients with cervical squamous cell carcinoma(SCC) and its clinicopathological grading.Methods:The data of 98 patients with SCC who had been treated from May 2017 to July 2022 were analyzed retrospectively.All the patients had undergone DCE MRI examination within one week before surgery,and the tumor pathological examinations of the patients were conducted after surgery.The clinicopathological parameters and the values of DCE MRI quantitative parameters,such as the volume transfer constant(Ktrans),the rate constant(Kep),and the extravascular extracellular space volume ratio(Ve) of the patients were collected.The values of Ktrans,Kep,and Ve were compared among the patients with different clinical stages,among the patients with different pathological grades,and among the patients with different lymph node metastases.Spearman correlation analysis was used to analyze the correlation between the values of Ktrans,Kep,and Ve of the patients and their clinicopathological grading.Results:In 98 patients with clinical T staging,there were 16 cases with stage Ⅰ,27 cases with stage Ⅱ,31 cases with stage Ⅲ,and 24 cases with stage Ⅳ.There were 33 cases with low tissue differentiation,41 cases with medium tissue differentiation,and 24 cases with high tissue differentiation.There were 26 cases with lymph node metastasis and 72 cases without lymph node metastasis.There were 68 cases with superficial myometrial invasion and 30 cases with deep myometrial invasion.The values of Ktrans,Kep,and Ve of the patients with stage Ⅰ-Ⅱ,stage Ⅲ,and stage Ⅳ of pathological staging had increased gradually.The values of Ktrans,Kep,and Ve of the patients with lymphatic metastasis were significantly higher than those of the patients without lymphatic metastasis(all P<0.05).Spearman correlation analysis showed that the quantitative parameters of Ktrans,Kep,and Ve in DCE MRI examination of the pa
作者
王露萍
李丽
李刚
谭益民
赵雄烽
WANG Luping;LI Li;LI Gang;TAN Yimin;ZHAO Xiongfeng(Keqiao Maternal and Child Health Care Hospital OF Shaoxing,Shaoxing,Zhejiang Province,312000;Shaoxing Maternal and Child Health Care Hospital)
出处
《中国计划生育学杂志》
2023年第10期2511-2514,2520,2521,共6页
Chinese Journal of Family Planning
关键词
宫颈鳞癌
动态增强磁共振成像
定量参数
病理分期
病理分级
相关性
Cervical squamous cell carcinoma
Dynamic contrast enhanced magnetic resonance imaging
Quantitative parameters
Pathological staging
Pathological grading
Correlation
